CD32
CD32 is a surface receptor protein and part of a large population of B cell co-receptors, which act to modulate signaling.
It has a low-affinity for IgG antibodies and down-regulates antibody production in the presence of IgG. This feedback loop acts to lower the production of IgG by B cells when there is a surplus in the body.
Monoclonal antibodies can distinguish between CD32A and CD32B.
References
↑ PDB: 2FCB; Sondermann P, Huber R, Jacob U. (March 1999). "Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution.". EMBO J. 18 (5): 1095–103. doi:10.1093/emboj/18.5.1095. PMC 1171201. PMID 10064577. ; rendered via PyMOL.
↑ Coico, R., Sunshine, G., and Benjamin, E. (2003). "Immunology: A Short Course" p.97.
↑ Veri MC, Gorlatov S, Li H; et al. (2007). "Monoclonal antibodies capable of discriminating the human inhibitory Fcgamma-receptor IIB (CD32B) from the activating Fcgamma-receptor IIA (CD32A): biochemical, biological and functional characterization". Immunology 121 (3): 392–404. doi:10.1111/j.1365-2567.2007.02588.x. PMC 2265948. PMID 17386079.
