This page is about "CD32" as a biological molecule. For the video game console please see Amiga CD32.
Fc fragment of IgG, low affinity IIa, receptor (CD32)
Identifiers
Symbol FCGR2A
Alt. symbols FCG2, FCGR2A1, FCGR2
Entrez 2212
HUGO 3616
OMIM 146790
RefSeq NM_021642
UniProt P12318
Other data
Locus Chr. 1 q23
Fc fragment of IgG, low affinity IIb, receptor (CD32)
CD32ray.png
Crystal structure of the human fcgamma-receptor IIb ectodomain (CD32).[1]
Identifiers
Symbol FCGR2B
Alt. symbols FCG2, FCGR2
Entrez 2213
HUGO 3618
OMIM 604590
RefSeq NM_004001
UniProt P31994
Other data
Locus Chr. 1 q23
Fc fragment of IgG, low affinity IIc, receptor for (CD32)
Identifiers
Symbol FCGR2C
Entrez 9103
HUGO 15626
RefSeq NM_201563
UniProt P31995
Other data
Locus Chr. 1 q23

CD32 is a surface receptor protein and part of a large population of B cell co-receptors, which act to modulate signaling.

It has a low-affinity for IgG antibodies and down-regulates antibody production in the presence of IgG. This feedback loops essentially lowers the production of IgG produced by B cells when there is a surplus in the body.[2]

Monoclonal antibodies can distinguish between type A and type B.[3]

References [link]

  1. ^ PDB 2FCB; Sondermann P, Huber R, Jacob U. (March 1999). "Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution.". EMBO J. 18 (5): 1095–103. DOI:10.1093/emboj/18.5.1095. PMC 1171201. PMID 10064577. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171201. ; rendered via PyMOL.
  2. ^ Coico, R., Sunshine, G., and Benjamin, E. (2003). "Immunology: A Short Course" p.97.
  3. ^ Veri MC, Gorlatov S, Li H, et al. (2007). "Monoclonal antibodies capable of discriminating the human inhibitory Fcgamma-receptor IIB (CD32B) from the activating Fcgamma-receptor IIA (CD32A): biochemical, biological and functional characterization". Immunology 121 (3): 392–404. DOI:10.1111/j.1365-2567.2007.02588.x. PMC 2265948. PMID 17386079. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2265948. 

External links [link]
1-50
51-100
101-150
151-200
201-250
251-300
301-350
Antibody receptor:
Fc receptor
FcγRI · FcγRII · FcγRIII · Neonatal
Secretory
Antigen receptor
Antigen receptor
stimulate: CD21/CD19/CD81
inhibit: CD22
Accessory molecules
Antigen receptor
TCR: TRA@ · TRB@ · TRD@ · TRG@
CD8 (with two glycoprotein chains CD8α and CD8β) · CD4
Accessory molecules
CD3 · CD3γ · CD3δ · CD3ε · ζ-chain (also called CD3ζ and TCRζ)
Cytokine receptor
Killer-cell IG-like receptors
Leukocyte IG-like receptors
LILRA1 · LILRA2 · LILRA3 · LILRA4 · LILRA5 · LILRA6 · LILRB1 · LILRB2 · LILRB3 · LILRB4 · LILRB5 · LILRA6 · LILRA5


Stub icon This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it.

https://wn.com/CD32

Podcasts:

Email this Page Play all in Full Screen Show More Related Videos
PLAYLIST TIME:

YOU GOT ME

by: Keith Sweat

[Lox]
Uh, yeah, uh huh, yeah
Yeah, yeah, yeah, uh huh, yeah, yeah
It's another one
Uh huh, yeah, yeah
It's another one, and another one
You got me where you want me
You could listen to Levert while leaving the country
And then sweat it out when you feel comfy
Or play Gill to the minute that ou say you're hungry
Uh, you got me where you want me
You could listen to Levert while leaving the country
And then sweat it out when you're feeling comfy
Or play gill to the minute that you say you're hungry
Uh, you got me where you want me
You could listen to Levert while leaving the country
And then Sweat it out when your'e feeling comfy
Or play Gill to the minute that you say you're hungry
[LSG]
I know
You need
Love and understanding
Sometimes
Feel like
I can't give you more of my time
You keep on wanting me
To be there girl
But I can't be
Why you keep stressing me
When you know I'm doing my best
I keep on telling you
I do the best that I can do
How can I get through to you
Everything I do is for you
1 - You got me where you want me
Tell me what you need
Take me baby
Tell me what you want
Anywhere you wanna go is for me
You got me where you want me
I can't keep on going through these changes
The more you doubt me
You keep pusing me away girl
You keep on wanting more
I'm doing my best
I'm doing everything for you
Repeat 1
Girl, you got me yearning
Yearning to know what I'll do with love
Can you tell me what I'm doing
But I'm always saying you don't understand
I'll never leave you alone
Repeat 1
Repeat Lox




×
×
×
×