T-cell surface glycoprotein CD3 zeta chain also known as T-cell receptor T3 zeta chain or CD247 (Cluster of Differentiation 247) is a protein that in humans is encoded by the CD247 gene.
The gene is located on the long arm of chromosome 1 at location 1q22-q25 on the Crick (negative) strand. The gene is 87,896 bases in length. The encoded protein is 164 amino acids long with a predicted weight of 18.696 kiloDaltons.
T-cell receptor zeta, together with T-cell receptor alpha/beta and gamma/delta heterodimers and CD3-gamma, -delta, and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
CD247 has been shown to interact with Janus kinase 3 and Protein unc-119 homolog.
[Verse:]
He gave his baby boy a bath
Tub full of bubbles and toys for him to splash
Look at daddy, soapsuds mustache
Funny faces and voices, it makes the baby belly laugh
Dry him off, now you squeaky clean
And watch the water spiral down that drain
Wrap him in a towel so he doesn't get the shivers
Brush his hair, it seems to help it dry it quicker
Laid him on mommy and daddy's bed now that he's dry
And put a diaper on him, gave him his pacifier
Superman pajamas, so tough
Innocent face full of unconditional love
Daddy picked him and rocked him slow
Never takes long for little guy's eyes to close
Dad's technique is different than your mother's
Never learned any lullabies, he sings Stevie Wonder's
There it is, steady breathing, sleep rhythm
Daddy sits and holds him just to listen for a minute
Daddy's hands are the meaning of security
And baby's hands are the evidence of purity
Thinking back to the day baby came
And how it changed the whole game, things ain't the same
Daddy had to stop running it crazy
Keep his ass in the home with the son and his lady
He was there for the birth and the first breath
Not gonna miss the first words or the first steps
Gonna keep the boy healthy and safe
And do his best to try to keep those tears off his face
Gave him a kiss, laid him in his crib
Turned out the lights, goodnight my little prince
That's how good daddy takes care of him