CD154
CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total CD40L has three binding partners: CD40, α5β1 integrin and αIIbβ3. CD154 acts as a costimulatory molecule and is particularly important on a subset of T cells called T follicular helper cells (TFH cells). On TFH cells, CD154 promotes B cell maturation and function by engaging CD40 on the B cell surface and therefore facilitating cell-cell communication. A defect in this gene results in an inability to undergo immunoglobulin class switching and is associated with hyper IgM syndrome. Absence of CD154 also stops the formation of germinal centers and therefore prohibiting antibody affinity maturation, an important process in the adaptive immune system.
Expression
CD40 ligand is primarily expressed on activated CD4+ T lymphocytes but is also found in a soluble form. While CD40L was originally described on T lymphocytes, its expression has since been found on a wide variety of cells, including platelets, mast cells, macrophages, basophils, NK cells, B lymphocytes, as well as non-haematopoietic cells (smooth muscle cells, endothelial cells, and epithelial cells).
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Good Daddy
by: Atmosphere[Verse:]
He gave his baby boy a bath
Tub full of bubbles and toys for him to splash
Look at daddy, soapsuds mustache
Funny faces and voices, it makes the baby belly laugh
Dry him off, now you squeaky clean
And watch the water spiral down that drain
Wrap him in a towel so he doesn't get the shivers
Brush his hair, it seems to help it dry it quicker
Laid him on mommy and daddy's bed now that he's dry
And put a diaper on him, gave him his pacifier
Superman pajamas, so tough
Innocent face full of unconditional love
Daddy picked him and rocked him slow
Never takes long for little guy's eyes to close
Dad's technique is different than your mother's
Never learned any lullabies, he sings Stevie Wonder's
There it is, steady breathing, sleep rhythm
Daddy sits and holds him just to listen for a minute
Daddy's hands are the meaning of security
And baby's hands are the evidence of purity
Thinking back to the day baby came
And how it changed the whole game, things ain't the same
Daddy had to stop running it crazy
Keep his ass in the home with the son and his lady
He was there for the birth and the first breath
Not gonna miss the first words or the first steps
Gonna keep the boy healthy and safe
And do his best to try to keep those tears off his face
Gave him a kiss, laid him in his crib
Turned out the lights, goodnight my little prince
That's how good daddy takes care of him