CD15
CD15 (3-fucosyl-N-acetyl-lactosamine) is a cluster of differentiation antigen - an immunologically significant molecule. CD15 is a carbohydrate adhesion molecule that can be expressed on glycoproteins, glycolipids and proteoglycans.
Function
CD15 mediates phagocytosis and chemotaxis, found on neutrophils; expressed in patients with Hodgkin disease, some B-cell chronic lymphocytic leukemias, acute lymphoblastic leukemias, and most acute nonlymphocytic leukemias. It is also called Lewis x and SSEA-1 (stage-specific embryonic antigen 1) and represents a marker for murine pluripotent stem cells, in which it plays an important role in adhesion and migration of the cells in the preimplantation embryo. It is synthezised by FUT4 (fucosyltransferase 4) and FUT9.
Diagnostic relevance
CD15 is present on almost all Reed–Sternberg cells, including their rare mononuclear variants, and, as such, can be used in immunohistochemistry to identify the presence of such cells in biopsies. The presence of these cells is diagnostic of Hodgkin's lymphoma. Reed-Sternberg cells display a characteristic pattern of CD15 positivity, with membranous staining combined with staining of the golgi apparatus. Immunohistochemical panels for the diagnosis of Hodgkins disease typically employ CD15 along with CD30 and CD45; the latter does not stain Reed-Sternberg cells, but does stain almost all other lymphoid cells. CD15 is also present in about 50% of adenocarcinoma cells and can be used to distinguish such conditions from mesothelioma, which is typically negative.
Podcasts:
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Kidd Video
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by Kidd Video
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by Kidd Video
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by Kidd Video
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by Kidd Kidd
YOU GOT ME
by: Keith Sweat[Lox]
Uh, yeah, uh huh, yeah
Yeah, yeah, yeah, uh huh, yeah, yeah
It's another one
Uh huh, yeah, yeah
It's another one, and another one
You got me where you want me
You could listen to Levert while leaving the country
And then sweat it out when you feel comfy
Or play Gill to the minute that ou say you're hungry
Uh, you got me where you want me
You could listen to Levert while leaving the country
And then sweat it out when you're feeling comfy
Or play gill to the minute that you say you're hungry
Uh, you got me where you want me
You could listen to Levert while leaving the country
And then Sweat it out when your'e feeling comfy
Or play Gill to the minute that you say you're hungry
[LSG]
I know
You need
Love and understanding
Sometimes
Feel like
I can't give you more of my time
You keep on wanting me
To be there girl
But I can't be
Why you keep stressing me
When you know I'm doing my best
I keep on telling you
I do the best that I can do
How can I get through to you
Everything I do is for you
1 - You got me where you want me
Tell me what you need
Take me baby
Tell me what you want
Anywhere you wanna go is for me
You got me where you want me
I can't keep on going through these changes
The more you doubt me
You keep pusing me away girl
You keep on wanting more
I'm doing my best
I'm doing everything for you
Repeat 1
Girl, you got me yearning
Yearning to know what I'll do with love
Can you tell me what I'm doing
But I'm always saying you don't understand
I'll never leave you alone
Repeat 1
Repeat Lox