Cluster of differentiation antigen 135 (CD135) also known as Fms-like tyrosine kinase 3 (FLT-3), receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the FLT3 gene. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. CD135 is the receptor for the cytokine Flt3 ligand (FLT3L).
It is expressed on the surface of many hematopoietic progenitor cells. Signalling of FLT3 is important for the normal development of haematopoietic stem cells and progenitor cells.
The FLT3 gene is one of the most frequently mutated genes in acute myeloid leukemia (AML). Besides, high levels of wild-type FLT3 have been reported for blast cells of some AML patients without FLT3 mutations. These high levels may be associated with worse prognosis.
FLT3 is composed of five extracellular immunoglobulin-like domains, a transmembrane domain, a juxtamembrane domain and a tyrosine-kinase domain consisting of 2 lobes that are connected by a tyrosine-kinase insert. Cytoplasmic FLT3 undergoes glycosylation, which promotes localization of the receptor to the membrane.
[Verse:]
He gave his baby boy a bath
Tub full of bubbles and toys for him to splash
Look at daddy, soapsuds mustache
Funny faces and voices, it makes the baby belly laugh
Dry him off, now you squeaky clean
And watch the water spiral down that drain
Wrap him in a towel so he doesn't get the shivers
Brush his hair, it seems to help it dry it quicker
Laid him on mommy and daddy's bed now that he's dry
And put a diaper on him, gave him his pacifier
Superman pajamas, so tough
Innocent face full of unconditional love
Daddy picked him and rocked him slow
Never takes long for little guy's eyes to close
Dad's technique is different than your mother's
Never learned any lullabies, he sings Stevie Wonder's
There it is, steady breathing, sleep rhythm
Daddy sits and holds him just to listen for a minute
Daddy's hands are the meaning of security
And baby's hands are the evidence of purity
Thinking back to the day baby came
And how it changed the whole game, things ain't the same
Daddy had to stop running it crazy
Keep his ass in the home with the son and his lady
He was there for the birth and the first breath
Not gonna miss the first words or the first steps
Gonna keep the boy healthy and safe
And do his best to try to keep those tears off his face
Gave him a kiss, laid him in his crib
Turned out the lights, goodnight my little prince
That's how good daddy takes care of him