Mast/stem cell growth factor receptor (SCFR), also known as proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117, is a receptor tyrosine kinase protein that in humans is encoded by the KIT gene. Multiple transcript variants encoding different isoforms have been found for this gene. KIT was first described by the German biochemist Axel Ullrich in 1987 as the cellular homolog of the feline sarcoma viral oncogene v-kit.
Cluster of differentiation (CD) molecules are markers on the cell surface, as recognized by specific sets of antibodies, used to identify the cell type, stage of differentiation and activity of a cell. CD117 is an important cell surface marker used to identify certain types of hematopoietic (blood) progenitors in the bone marrow. To be specific, hematopoietic stem cells (HSC), multipotent progenitors (MPP), and common myeloid progenitors (CMP) express high levels of CD117. Common lymphoid progenitors (CLP) express low surface levels of CD117. CD117 also identifies the earliest thymocyte progenitors in the thymus. To be specific, early T lineage progenitors (ETP/DN1) and DN2 thymocytes express high levels of c-Kit. It is also a marker for mouse prostate stem cells. In addition, mast cells, melanocytes in the skin, and interstitial cells of Cajal in the digestive tract express CD117.
[Verse:]
He gave his baby boy a bath
Tub full of bubbles and toys for him to splash
Look at daddy, soapsuds mustache
Funny faces and voices, it makes the baby belly laugh
Dry him off, now you squeaky clean
And watch the water spiral down that drain
Wrap him in a towel so he doesn't get the shivers
Brush his hair, it seems to help it dry it quicker
Laid him on mommy and daddy's bed now that he's dry
And put a diaper on him, gave him his pacifier
Superman pajamas, so tough
Innocent face full of unconditional love
Daddy picked him and rocked him slow
Never takes long for little guy's eyes to close
Dad's technique is different than your mother's
Never learned any lullabies, he sings Stevie Wonder's
There it is, steady breathing, sleep rhythm
Daddy sits and holds him just to listen for a minute
Daddy's hands are the meaning of security
And baby's hands are the evidence of purity
Thinking back to the day baby came
And how it changed the whole game, things ain't the same
Daddy had to stop running it crazy
Keep his ass in the home with the son and his lady
He was there for the birth and the first breath
Not gonna miss the first words or the first steps
Gonna keep the boy healthy and safe
And do his best to try to keep those tears off his face
Gave him a kiss, laid him in his crib
Turned out the lights, goodnight my little prince
That's how good daddy takes care of him