chemokine (C-C motif) ligand 27
Identifiers
Symbol CCL27
Alt. symbols SCYA27, ALP, ILC, CTACK, skinkine, ESkine, PESKY, CTAK
Entrez 10850
HUGO 10626
OMIM 604833
RefSeq NM_006664
UniProt Q9Y4X3
Other data
Locus Chr. 9 q13

Chemokine (C-C motif) ligand 27 (CCL27) is a small cytokine belonging to the CC chemokine family also known under the names IL-11 R-alpha-locus chemokine (ILC), Skinkine, ESkine and Cutaneous T-cell-attracting chemokine (CTACK). It is associated with homing of memory T lymphocytes to the skin, and plays a role in T cell-mediated inflammation of the skin.[1][2] CCL27 is expressed in numerous tissues, including gonads, thymus, placenta and skin. It elicits its chemotactic effects by binding to the chemokine receptor CCR10.[3] The gene for CCL27 is located on human chromosome 9.[4]

References [link]

  1. ^ Morales et al. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Proc. Natl. Acad. Sci. U.S.A. 96:14470-14475, 1999.
  2. ^ Homey et al. CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Nature Med. 8: 157-165, 2002.
  3. ^ Homey et al. The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). J. Immunol. 164:3465-3470, 2000.
  4. ^ Ishikawa-Mochizuki et al. Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus. FEBS Lett. 460:544-548, 1999.
By family
CCL
CCL1 · CCL2/MCP-1 · CCL3/MIP-1α · CCL4/MIP-1β · CCL5/RANTES · CCL6 · CCL7 · CCL8 · CCL9 · CCL11 · CCL12 · CCL13 · CCL14 · CCL15 · CCL16 · CCL17 · CCL18 · CCL19 · CCL20 · CCL21 · CCL22 · CCL23 · CCL24 · CCL25 · CCL26 · CCL27 · CCL28
CXCL
CXCL1/KC · CXCL2 · CXCL3 · CXCL4 · CXCL5 · CXCL6 · CXCL7 · CXCL8/IL8 · CXCL9 · CXCL10 · CXCL11 · CXCL12 · CXCL13 · CXCL14 · CXCL15 · CXCL16 · CXCL17
CX3CL
XCL
Type I
(grouped by
receptor
subunit)
IL2/IL15 · IL4/IL13 · IL7 · IL9 · IL21
IL3 · IL5 · GM-CSF
IL6 like/gp130
IL6  · IL11 · IL27 · IL30 · IL31 (+non IL OSM, LIF, CNTF, CTF1)
IL12 · IL23 · IL27 · IL35
Other
IL14 · IL16 · IL32  · IL34
Other
By function/
cell


Stub icon This article on a gene on chromosome 9 is a stub. You can help Wikipedia by expanding it.

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Maybe you were right and i was wrong
But nonetheless this is my final song
Maybe you were right and i was wrong
But nonetheless this is my final song
I’m moving on to a better place
Nightmares don’t arrive when i see your face
Cannot hold on to a bitter past
Candles like us were never meant to last
Maybe you were right and i was wrong




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