California's 8th congressional district

California's 8th congressional district is a congressional district in the U.S. state of California.

Paul Cook, a Republican from Yucca Valley, has represented the district since January 2013.

Currently, the 8th district encompasses most of the eastern desert regions of the state. It stretches from Mono Lake to Twentynine Palms. It consists of Inyo and Mono counties plus most of San Bernardino County. It is one of the largest and most sparsely populated congressional districts in California. The largest city in the district is Victorville.

Prior to redistricting by the California Citizens Redistricting Commission of 2011, the 8th district was in San Francisco. The new district lines went into effect for the June 2012 elections.

Demographics

The district is 50.2% white, 8.1% black, 3.9% Asian, 35.3% Hispanic, and 2.5% other. Among registered voters, 41.9% are registered with the Republican Party and 32.6% are registered with the Democratic Party. Voters affiliated with other or no parties make up 25.6% of the electorate.

CA8

Carbonic anhydrase-related protein is an enzyme that in humans is encoded by the CA8 gene.

Function

The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form.

Interactions

CA8 has been shown to interact with ITPR1.

References

Further reading