CADPS2

Calcium-dependent secretion activator 2 is a protein that in humans is encoded by the CADPS2 gene.

Function

This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium-binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells.

Interactions

This gene interacts with brain-derived neurotrophic factor.

Clinical significance

Cadps2 has been linked to autism and is in the 7q autism susceptibility locus (AUTS1). However, the finding of aberrant CADPS2 splicing was not found to be significant in another study.

A knockout mouse model was found to have autistic-like characteristics.

CADPS2 has been linked to human and mouse brain structure in two large genomic studies.

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

CADPS

Calcium-dependent secretion activator 1 is a protein that in humans is encoded by the CADPS gene.

CADPS encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. CADPS acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described.

References

Further reading