complement component 1, q subcomponent, A chain
Identifiers
Symbol C1QA
Entrez 712
HUGO 1241
OMIM 120550
RefSeq NM_015991
UniProt P02745
Other data
Locus Chr. 1 p36.3-34.1
complement component 1, q subcomponent, B chain
Identifiers
Symbol C1QB
Entrez 713
HUGO 1242
OMIM 120570
RefSeq NM_000491
UniProt P02746
Other data
Locus Chr. 1 p36.3-34.1
complement component 1, q subcomponent, C chain
Identifiers
Symbol C1QC
Alt. symbols C1QG
Entrez 714
HUGO 1245
OMIM 120575
RefSeq NM_172369
UniProt P02747
Other data
Locus Chr. 1 p36.11

The C1q complex is potentially multivalent for attachment to the complement fixation sites of immunoglobulin.

The sites are on the CH2 domain of IgG and, it is thought, on the CH4 domain of IgM.

The appropriate peptide sequence of the complement fixing site might become exposed following complexing of the immunoglobulin, or the sites might always be available, but might require multiple attachment by C1q with critical geometry in order to achieve the necessary avidity.

Structure [link]

C1q is a 400kDa protein formed from 18 peptide chains in 3 subunits of 6. Each 6 peptide subunit consists of a Y-shaped pair of triple peptide helices joined at the stem and ending in a globular non-helical head.


The 80-amino acid helical component of each triple peptide contain many Gly-X-Y sequences, where X and Y are proline, isoleucine, or hydroxylysine; they, therefore, strongly resemble collagen fibrils.

Function [link]

The classical and alternative complement pathways.

It is assumed that the globular ends are the sites for multivalent attachment to the complement fixing sites in immune complexed immunoglobulin. Patients suffering from Lupus erythematosus often have deficient expression of C1q.

External links [link]
Activators/enzymes
Early
Middle
Late
MAC (C6, C7, C8, C9)
Inhibitors
Complement receptors
Stub icon This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it.

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Podcasts:

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PLAYLIST TIME:

All That I Want

by: C21

ALL THAT I WANT / C21
I just need you to know
That everytime you walk into a room I get a feeling
And I try to make it show
But every now and then it seems as though you don't believe it
Girl just dance
I like the way you move it
Just shake, shake, shake into the music
C'mon and dance
Don't worry about it
Don't need to play no games 'cause I love you just the same
(You turn) me on and on turn me on
The definition of all that I want
But you don't seem to hear me at all
I'm telling you
Baby you're all that I want
All that I want
All that I know
is your the only one that makes me feel the way you do girl
And time will show
That all this jealousy is just a waste of emotion
Girl just dance
I like the way you move it
Just shake, shake, shake into the music
C'mon and dance
Don't worry about it
Don't need to play no games 'cause I love you just the same
(You turn) me on and on turn me on
The definition of all that I want
But you don't seem to hear me at all
I'm telling you
Baby you're all that I want
All that I want
Just hear me now
I want you to know
I'm into you
And you alone
Just hear me now
I want you to know
I'm into you
And you alone
Girl just dance
I like the way you move it
Just shake, shake, shake into the music
C'mon and dance
Don't worry about it
Don't need to play no games 'cause I love you just the same
(You turn) me on and on turn me on
The definition of all that I want
But you don't seem to hear me at all
I'm telling you
Baby you're all that I want
(You) turn me on and on turn me on
The definition of all that I want
But you don't seem to hear me at all
I'm telling you
Baby you're all that I want
You're turning me on girl
C'mon and just dance girl
You're making me sweat girl




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