Hereditary multiple exostoses

Hereditary multiple exostoses (HME or MHE), also known as Diaphyseal aclasis, is a rare medical condition in which multiple bony spurs or lumps (also known as exostoses, or osteochondromas) develop on the bones of a child. HME is synonymous with Multiple hereditary exostoses and Multiple osteochondromatosis, which is the preferred term used by the World Health Organization.

Pathophysiology

It is characterized by the growth of cartilage-capped benign bone tumours around areas of active bone growth, particularly the metaphysis of the long bones. Typically five or six exostoses are found in upper and lower limbs. Most common locations are:

HME can lead to the shortening and bowing of bones; affected individuals often have a short stature. Depending on their location the exostoses can cause the following problems: pain or numbness from nerve compression, vascular compromise, inequality of limb length, irritation of tendon and muscle, Madelung's deformity as well as a limited range of motion at the joints upon which they encroach. A person with HME has an increased risk of developing a rare form of bone cancer called chondrosarcoma as an adult. Problems may be had in later life and these could include weak bones and nerve damage. The reported rate of transformation ranges from as low as 0.57% to as high as 8.3% of people with HME.

Buffalo (footwear)

Buffalo is a brand of clothing and accessories, perhaps best known for its footwear, owned by the Buffalo Boots GmbH. Its headquarters are in Hochheim am Main, Germany.

Buffalo's notoriety increased significantly with the popularity, especially in Europe, of its platform shoes from the mid-1990s through the early 2000s. The 10-centimetre platform model 1310-2 was made famous by British girl band the Spice Girls. The 1310-2 also came with a 20-centimetre platform.

Buffalo manufactures women's shoes, men's shoes like dress shoes, western and biker boots, skate shoes, high heels, pumps, sandals, overknee boots,flip-flops, and other footwear, as well as shirts, jackets, trousers, skirts, hosiery, swimsuits, undergarments, and small baggage.

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Buffalo (band)

Buffalo were an Australian rock band formed in August 1971 by founding mainstay Dave Tice on lead vocals (ex-Head). Fellow founders, also from Head, were Paul Balbi on drums, John Baxter on guitar, and Peter Wells on bass guitar; together with Alan Milano on lead vocals (ex-Mandala). Milano left after their debut album, Dead Forever... (June 1972), and Balbi was replaced on drums by Jimmy Economou. Their next two albums, Volcanic Rock (July 1973) and Only Want You For Your Body (June 1974), were also issued by Vertigo Records. After 1975 line-up changes resulted in a more commercial sound and the group disbanded in March 1977. Australian musicologist, Ian McFarlane, noted that there was "nothing subtle about Buffalo's primal, heavyweight sound, but it was delivered with a great deal of conviction ... combining the dense, occult riffing ... with the progressive blues chops ... the band certainly captured the arrogant disposition of the times in a bold and thunderous fashion". Alongside Billy Thorpe & The Aztecs and Blackfeather, Buffalo pioneered Australia's heavy metal, pub rock and alternative rock movements. Peter Wells died on 27 March 2006, aged 58.

Black Buffalo (wrestler)

Keisuke Yamada (山田 圭介, Yamada Keisuke, born July 6, 1974) is a Japanese professional wrestler, better known by the ring name Black Buffalo (ブラックバファロー, Burakku Bafarō). Originally starting his career in International Wrestling Association of Japan, where he worked under his real name, Yamada found a new home promotion in 1999 in Osaka Pro Wrestling, where he began wrestling under a mask and the ring name Black Buffalo. For most of his career in Osaka Pro, Yamada has portrayed a villainous character, having been a part of every major villainous alliance in the history of the promotion. During his first years in the promotion, Buffalo went on to become a four-time Tag Team Champion. In February 2008, Buffalo was forced to unmask and reveal his true identity, after losing a match, and afterwards began teaming with the man, who unmasked him, Tigers Mask, with two becoming two-time Osaka Pro Wrestling Tag Team Champions together. Finally, in March 2012, Buffalo managed to win Osaka Pro's top title, the Osaka Pro Wrestling Championship. Backstage, Yamada served as the vice president of Osaka Pro Wrestling. Yamada left Osaka Pro Wrestling after the promotion went through a corporate restructuring in April 2014, shortening his ring name to Buffalo (バッファロー, Baffarō).