Budiodarone
Budiodarone (ATI-2042) is an antiarrhythmic agent and chemical analog of amiodarone that is currently being studied in clinical trials. Amiodarone is considered the most effective antiarrhythmic drug available, but its adverse side effects, including hepatic, pulmonary and thyroid toxicity as well as multiple drug interactions, are discouraging its use. Budiodarone only differs in structure from amiodarone through the presence of a sec-butyl acetate side chain at position 2 of the benzofuran moiety. This side chain allows for budiodarone to have a shorter half-life in the body than amiodarone (7 hours versus 35–68 days) which allows it to have a faster onset of action and metabolism while still maintaining similar electrophysiological activity. The faster metabolism of budiodarone allows for fewer adverse side effects than amiodarone principally due to decreased levels of toxicity in the body.
Creation of arrythmias
Arrhythmias may be caused by changes in ion channel mRNA and protein expression which modify action potential generation through dysfunctional channels and increase the likelihood of inappropriate electrical re-entry (electrical stimulus entering back into the cell to prematurely start the next action potential). The increase in electrical re-entry causes the fibrillation or uncontrolled action potential discord of atrial myocytes. Arrhythmias have historically been treated using atrial ablation or antiarrhythmic drugs to decrease electrical re-entry and therefore fibrillation.
Podcasts:
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by The Allman Brothers Band
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by Allman Brothers Band
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by Allman Brothers
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by Widowmaker
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by Slash
Bad Rain
by: The Allman Brothers BandDon't come around here no more,
bringing me all of your bad rain.
Can't you see I've got troubles of my own.
I ain't got time to be messing with all of your bad rain,
why in the world can't you just leave that stuff alone?
There was a time we had a good thing going on,
you and I both know the reason why it all went wrong.
Tried to stick by you, help you see it through,
but you used me all up, now you're on your own.
So, don't come around here no more,
bringing me all of your bad rain.
Can't you see I've got troubles of my own.
I ain't got time to be messing with all of your bad rain,
why in the world can't you just leave that stuff alone?
Well I tried and tried again, to be good to you,
but you won't a hear a word and I don't know what it's coming to.
Comes a time when you just have to turn and, walk away,
there's nothing left to do, nothing left to say.
So, don't come around here no more,
bringing me all of your bad rain.
Can't you see I've got troubles of my own.
I ain't got time to be messing with all of your bad rain,
why in the world can't you just leave that stuff alone?
I ain't someone to be preaching to nobody else,
ain't going to try and pretend to be living that clean myself.
Can't stand by and watch you throw your life away,
But there's nothing left to do, nothing left to say.
So, don't come around here no more,
bringing me all of your bad rain.
Can't you see I've got troubles of my own.
I ain't got time to be messing with all of your bad rain,
why in the world can't you just leave that stuff alone?
Why in the world can't you just leave that stuff alone?