Mitotic checkpoint serine/threonine-protein kinase BUB1 beta is an enzyme that in humans is encoded by the BUB1B gene.[1]
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.[2]
Interactions [link]
BUB1B has been shown to interact with AP2B1,[3] HDAC1,[4] BUB3,[3][5][6] MAD2L1,[5] Gamma-synuclein,[7] BRCA2[8] and CDC20.[5][9][10][11][12][13]
References [link]
- ^ Davenport JW, Fernandes ER, Harris LD, Neale GA, Goorha R (March 1999). "The mouse mitotic checkpoint gene bub1b, a novel bub1 family member, is expressed in a cell cycle-dependent manner". Genomics 55 (1): 113–7. DOI:10.1006/geno.1998.5629. PMID 9889005.
- ^ "Entrez Gene: BUB1B BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=701.
- ^ a b Cayrol, Corinne; Cougoule Céline, Wright Michel (November 2002). "The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint kinase BubR1". Biochem. Biophys. Res. Commun. (United States) 298 (5): 720–30. DOI:10.1016/S0006-291X(02)02522-6. ISSN 0006-291X. PMID 12419313.
- ^ Yoon, Young-Mee; Baek Kwan-Hyuck, Jeong Sook-Jung, Shin Hyun-Jin, Ha Geun-Hyoung, Jeon Ae-Hwa, Hwang Sang-Gu, Chun Jang-Soo, Lee Chang-Woo (September 2004). "WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase". FEBS Lett. (Netherlands) 575 (1–3): 23–9. DOI:10.1016/j.febslet.2004.07.089. ISSN 0014-5793. PMID 15388328.
- ^ a b c Sudakin, V; Chan G K, Yen T J (September 2001). "Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2". J. Cell Biol. (United States) 154 (5): 925–36. DOI:10.1083/jcb.200102093. ISSN 0021-9525. PMC 2196190. PMID 11535616. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2196190.
- ^ Taylor, S S; Ha E, McKeon F (July 1998). "The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase". J. Cell Biol. (UNITED STATES) 142 (1): 1–11. DOI:10.1083/jcb.142.1.1. ISSN 0021-9525. PMC 2133037. PMID 9660858. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2133037.
- ^ Gupta, Anu; Inaba Satoru, Wong Oi Kwan, Fang Guowei, Liu Jingwen (October 2003). "Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1". Oncogene (England) 22 (48): 7593–9. DOI:10.1038/sj.onc.1206880. ISSN 0950-9232. PMID 14576821.
- ^ Futamura, M; Arakawa H, Matsuda K, Katagiri T, Saji S, Miki Y, Nakamura Y (March 2000). "Potential role of BRCA2 in a mitotic checkpoint after phosphorylation by hBUBR1". Cancer Res. (UNITED STATES) 60 (6): 1531–5. ISSN 0008-5472. PMID 10749118.
- ^ Fang, Guowei (March 2002). "Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex". Mol. Biol. Cell (United States) 13 (3): 755–66. DOI:10.1091/mbc.01-09-0437. ISSN 1059-1524. PMC 99596. PMID 11907259. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99596.
- ^ Wu, H; Lan Z, Li W, Wu S, Weinstein J, Sakamoto K M, Dai W (September 2000). "p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase". Oncogene (ENGLAND) 19 (40): 4557–62. DOI:10.1038/sj.onc.1203803. ISSN 0950-9232. PMID 11030144.
- ^ Kallio, Marko J; Beardmore Victoria A, Weinstein Jasminder, Gorbsky Gary J (September 2002). "Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells". J. Cell Biol. (United States) 158 (5): 841–7. DOI:10.1083/jcb.200201135. ISSN 0021-9525. PMC 2173153. PMID 12196507. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173153.
- ^ Skoufias, D A; Andreassen P R, Lacroix F B, Wilson L, Margolis R L (April 2001). "Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (8): 4492–7. DOI:10.1073/pnas.081076898. ISSN 0027-8424. PMC 31862. PMID 11274370. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=31862.
- ^ Nilsson, Jakob; Yekezare Mona, Minshull Jeremy, Pines Jonathon (December 2008). "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction". Nat. Cell Biol. (England) 10 (12): 1411–20. DOI:10.1038/ncb1799. PMC 2635557. PMID 18997788. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2635557.
Further reading [link]
- Posas F, Saito H (1998). "Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two-component response regulator". EMBO J. 17 (5): 1385–94. DOI:10.1093/emboj/17.5.1385. PMC 1170486. PMID 9482735. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170486.
- Cahill DP, Lengauer C, Yu J, et al. (1998). "Mutations of mitotic checkpoint genes in human cancers". Nature 392 (6673): 300–3. DOI:10.1038/32688. PMID 9521327.
- Donadelli R, Benatti L, Remuzzi A, et al. (1998). "Identification of a novel gene--SSK1--in human endothelial cells exposed to shear stress". Biochem. Biophys. Res. Commun. 246 (3): 881–7. DOI:10.1006/bbrc.1998.8713. PMID 9618306.
- Taylor SS, Ha E, McKeon F (1998). "The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase". J. Cell Biol. 142 (1): 1–11. DOI:10.1083/jcb.142.1.1. PMC 2133037. PMID 9660858. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2133037.
- Chan GK, Schaar BT, Yen TJ (1998). "Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1". J. Cell Biol. 143 (1): 49–63. DOI:10.1083/jcb.143.1.49. PMC 2132809. PMID 9763420. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2132809.
- Jablonski SA, Chan GK, Cooke CA, et al. (1999). "The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis". Chromosoma 107 (6–7): 386–96. DOI:10.1007/s004120050322. PMID 9914370.
- Cahill DP, da Costa LT, Carson-Walter EB, et al. (1999). "Characterization of MAD2B and other mitotic spindle checkpoint genes". Genomics 58 (2): 181–7. DOI:10.1006/geno.1999.5831. PMID 10366450.
- Chan GK, Jablonski SA, Sudakin V, et al. (1999). "Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC". J. Cell Biol. 146 (5): 941–54. DOI:10.1083/jcb.146.5.941. PMC 2169490. PMID 10477750. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2169490.
- Li W, Lan Z, Wu H, et al. (2000). "BUBR1 phosphorylation is regulated during mitotic checkpoint activation". Cell Growth Differ. 10 (11): 769–75. PMID 10593653.
- Futamura M, Arakawa H, Matsuda K, et al. (2000). "Potential role of BRCA2 in a mitotic checkpoint after phosphorylation by hBUBR1". Cancer Res. 60 (6): 1531–5. PMID 10749118.
- Wu H, Lan Z, Li W, et al. (2000). "p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase". Oncogene 19 (40): 4557–62. DOI:10.1038/sj.onc.1203803. PMID 11030144.
- Saffery R, Irvine DV, Griffiths B, et al. (2001). "Components of the human spindle checkpoint control mechanism localize specifically to the active centromere on dicentric chromosomes". Hum. Genet. 107 (4): 376–84. DOI:10.1007/s004390000386. PMID 11129339.
- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. DOI:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1083732.
- Skoufias DA, Andreassen PR, Lacroix FB, et al. (2001). "Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints". Proc. Natl. Acad. Sci. U.S.A. 98 (8): 4492–7. DOI:10.1073/pnas.081076898. PMC 31862. PMID 11274370. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=31862.
- Kaplan KB, Burds AA, Swedlow JR, et al. (2001). "A role for the Adenomatous Polyposis Coli protein in chromosome segregation". Nat. Cell Biol. 3 (4): 429–32. DOI:10.1038/35070123. PMID 11283619.
- Sudakin V, Chan GK, Yen TJ (2001). "Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2". J. Cell Biol. 154 (5): 925–36. DOI:10.1083/jcb.200102093. PMC 2196190. PMID 11535616. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2196190.
- Tang Z, Bharadwaj R, Li B, Yu H (2001). "Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1". Dev. Cell 1 (2): 227–37. DOI:10.1016/S1534-5807(01)00019-3. PMID 11702782.
- Shichiri M, Yoshinaga K, Hisatomi H, et al. (2002). "Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival". Cancer Res. 62 (1): 13–7. PMID 11782350.
- Taylor SS, Hussein D, Wang Y, et al. (2002). "Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells". J. Cell. Sci. 114 (Pt 24): 4385–95. PMID 11792804.
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Ball and Chain
by: B4-4I just wanna be your ball and chain
Wrapped around your finger
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I never wanted to stay
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you know that I get open when you rubbing my back the goose bumps
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I just wanna be your ball and chain
Wrapped around your finger
Locked up, tied me down
Follow you forever
Never let you get away,