The Broadkill flows for its entire length in eastern Sussex County. It issues from Wagamons Pond in the town of Milton; the pond is fed by two tributaries known as Ingram Branch and Pemberton Branch. From Milton, the Broadkill River flows generally eastwardly, passing through wetlands and salt marshes in the Prime Hook National Wildlife Refuge. After approaching to within one quarter mile (0.5km) of Delaware Bay, the river parallels the shoreline a short distance inland for approximately two miles (3km) before flowing into the bay, approximately one mile (1.6km) northwest of Lewes. The United States Coast Guard maintains a station near the mouth of the Broadkill. The mouth is connected to Rehoboth Bay by the Lewes and Rehoboth Canal, which forms part of the Atlantic Intracoastal Waterway.