Prussian Heritage Image Archive
The Prussian Heritage Image Archive (German: Bildarchiv Preußischer Kulturbesitz or 'bpk') is an agency of the Prussian Cultural Heritage Foundation. The archive is housed at the Otto Nagel-Haus in Berlin, Germany and offers photographs, cartoons and drawings in the fields of history, culture and fine arts. The collection also contains the personal estates, archives and portfolios of many famous photographers who documented life in Germany. Organizationally, the archive is a division of the Berlin State Library.
History
The core of the collection was built in 1966 from the historical picture library of Hermann Handke. This stock consists of about 1 million daguerrotypes, talbotypes, photographic prints, negatives, engravings and lithographs. Through targeted acquisitions, donations and estate gifts, bpk's collection has grown to over 12 million photographs today and is one of the largest in Europe.
The Collection
Photographs documenting contemporary German history form the vast majority of the collection. Photographs of works of fine arts and culture from famous museums around the world are the second main focus.
Bruton's tyrosine kinase
Bruton's tyrosine kinase (abbreviated Btk or BTK) also known as tyrosine-protein kinase BTK is an enzyme that in humans is encoded by the BTK gene. BTK is a kinase that plays a crucial role in B-cell development.
Function
BTK plays a crucial role in B cell maturation as well as mast cell activation through the high-affinity IgE receptor.
Btk contains a PH domain that binds phosphatidylinositol (3,4,5)-trisphosphate (PIP3). PIP3 binding induces Btk to phosphorylate phospholipase C, which in turn hydrolyzes PIP2, a phosphatidylinositol, into two second messengers, inositol triphosphate (IP3) and diacylglycerol (DAG), which then go on to modulate the activity of downstream proteins during B-cell signalling.
Clinical significance
Mutations in the BTK gene are implicated in the primary immunodeficiency disease X-linked agammaglobulinemia (Bruton's agammaglobulinemia). Patients with XLA have normal pre-B cell populations in their bone marrow but these cells fail to mature and enter the circulation. The Btk gene is located on the X chromosome. At least 400 mutations of the BTK gene have been identified.
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Santa Hooked Me Up
by: B2kThis year your boy went all out
Let me sit down and tell you what I'm talkin' about
Now what's somthin' you can imagine
So I don't have to explain
Oh, just picture the North Pole
Relaxin' in my chain and my girl
She's bad, so bad, whoa
Havin' a girl like Boog's gonna become the new fad
When you're walkin' to my house
You're gonna be given a map
'Cuz if you turn the wrong corner
You won't find your way back
But I'm sleepy now
So, I'm gone off the track
Bye, goodnight, holla
Santa hooked me up this year
Santa hooked me up this year
Santa hooked me up this year
So let me tell you what I got for Christmas this year
Santa hooked me up this year
Santa hooked me up this year
Santa hooked me up this year
So let me tell you what I got for Christmas this year
Santa hooked me up with a Bentley 4 door
Now a 100 million dolla G4
Santa was generous
Gave me a gang of money
More ice than the North Pole
More karats than Bugs Bunny
This year forget the socks
And the Christmas tree
I got a Benz 1200
Ain't even hit the streets
I got a 3-way pager and a matching set
Got an iced out chain that put a crick in my neck
Santa hooked me up this year
Santa hooked me up this year
Santa hooked me up this year
So let me tell you what I got for Christmas this year
Santa hooked me up this year
Santa hooked me up this year
Santa hooked me up this year
So let me tell you what I got for Christmas this year
This year my gift was too sick
Santa Claus got me that 6
With that doubled out kit
Too clean, fresh white, gangsta lean
You know how I do, when Inn get on the scene
Santa Claus, "SC" is what I call his name
He give me too much I think Santa got crazy
But anyways, thank you for all the gifts
I left them hot cookies, but just forget it
Santa hooked me up this year
Santa hooked me up this year
Santa hooked me up this year
So let me tell you what I got for Christmas this year
Santa hooked me up this year
Santa hooked me up this year
Santa hooked me up this year
So let me tell you what I got for Christmas this year
Now Christmas is my favorite time of year
I got red forces with red Polo gear
Red Chanel ski hat, plus a Cadillac
With diamond in the back
Sittin' on the scene with shiny gold D's
Oh, ice crush soda can
Chrome on the left hand
And a walkman, you got a walkman
When I got all this
Man I thought it was great
But I was bad this year
So Santa made a mistake
Santa hooked me up this year
Santa hooked me up this year
Santa hooked me up this year
So let me tell you what I got for Christmas this year
Santa hooked me up this year
Santa hooked me up this year
Santa hooked me up this year
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