Ago

Ago or AGO may refer to:

People

Places

Other uses

Argonaute

The Argonaute protein family plays a central role in RNA silencing processes, as essential catalytic components of the RNA-induced silencing complex (RISC). RISC complex is responsible for the gene silencing phenomenon known as RNA interference (RNAi). Argonaute proteins bind different classes of small non-coding RNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). Small RNAs guide Argonaute proteins to their specific targets through sequence complementarity (base pairing), which then leads to mRNA cleavage or translation inhibition.

Discovery

The RNA interference (RNAi) was first reported in 1995 by Guo and Kemphues, and similar pathways collectively referred to as RNA silencing were discovered in plants and fungi. The beginning of people’s understanding of the mechanism of RNA silencing began only in 1998 with the experiments of Fire and colleagues demonstrating that double-stranded RNA triggered RNAi. RNA silencing pathways process long RNAs into small RNAs that direct the repression of transcription or translation of nucleic acid targets with sequence corresponding to the small RNAs. These single-stranded RNAs, referred to as guide strands, are incorporated into RNA silencing effectors complexes such as the RNA-induced silencing complex (RISC). These RNA silencing effector complexes contain Argonaute family proteins.

Aaron's Party (Come Get It)

Aaron's Party (Come Get It) is American pop singer Aaron Carter's second studio album serving as the follow-up to his international debut album. This album was released in the fall of 2000 becoming the first album under Jive Records. This album was also certified 3× Platinum by the RIAA for selling over 3 million copies in the United States making it Aaron's most successful album. The lead single "Aaron's Party (Come Get It)" was featured on the 2000 compilation album Now That's What I Call Music! 5.

Track listing

Bounce (Sarah Connor song)

"Bounce" is a song by German recording artist Sarah Connor, taken from her second studio album, Unbelievable (2002). Written by Bülent Aris, Toni Cottura, and Anthony Freeman, with production helmed by the former, the uptempo pop song samples Mary J. Blige's 2001 song "Family Affair", while featuring guest vocals by Wyclef Jean. "Bounce" was originally released as the album's fourth and final single in Central Europe on 21 July 2003, amid Connor's first pregnancy. It reached the top twenty in Austria, Germany, Switzerland, and Walloon Region of Belgium.

In winter 2003 radio programmers Tod Tucker and Matt "the bratt" Derrick at 106.9 K-HITS in Tulsa, Oklahoma took hold of a copy of the single and began to give it airplay. Due to large amounts of airplay in the United States, the song reached number eleven on Billboard's Top 40 Mainstream and number twenty-one on Top 40 Tracks charts, eventually charting on the Billboard Hot 100 at number fifty-four. "Bounce" was officially given a physical US release on 4 May 2004, serving as Connor's debut single there. It was also released in Australia and the United Kingdom, where it reached number 14 on both charts. The radio version of the song was featured on the 2004 compilation album Now That's What I Call Music! 15.

Bounce (golf)

In golf, bounce or bounce angle is the angle inscribed by the leading edge of a golfing iron (particularly a wedge), the sole of the club, and the ground. In plainer terms, bounce angle is an indication of how much the sole, or bottom-most part, of the club head lifts the leading edge. A high bounce angle (angles of 12–15° are not uncommon) indicates a sole which lifts the leading edge significantly, whereas a club with little or no bounce allows the leading edge to contact the ground without interference.

The purpose of introducing bounce into club head design is to control how easily wedges, with their steep angles of attack, penetrate the ground under the ball. A low- or zero-bounce club has a streamlined profile, and the sharp leading edge of the club will tend to cut into the ground readily. When this is undesirable, the use of a club with more bounce will cause the sole of the club to impact first, keeping the wedge from digging into the surface by causing it to "bounce" across the surface instead.