Bone marrow suppression
Bone marrow suppression or myelotoxicity (adjective myelotoxic) or myelosuppression is the decrease in production of cells responsible for providing immunity (leukocytes), carrying oxygen (erythrocytes), and/or those responsible for normal blood clotting (thrombocytes). Bone marrow suppression is a serious side effect of chemotherapy and certain drugs affecting the immune system such as azathioprine. The risk is especially high in cytotoxic chemotherapy for leukemia.
Non-steroidal anti-inflammatory drugs, in some rare instances, may also cause bone marrow suppression. The decrease in blood cell counts does not occur right at the start of chemotherapy because the drugs do not destroy the cells already in the bloodstream (these are not dividing rapidly). Instead, the drugs affect new blood cells that are being made by the bone marrow. When myelosuppression is severe, it is called myeloablation.
Because the bone marrow is the manufacturing center of blood cells, the suppression of bone marrow activity causes a deficiency of blood cells. This condition can rapidly lead to life-threatening infection, as the body cannot produce leukocytes in response to invading bacteria and viruses, as well as leading to anaemia due to a lack of red blood cells and spontaneous severe bleeding due to deficiency of platelets.
Bone marrow
Bone marrow is the flexible tissue in the interior of bones. In humans, red blood cells are produced by cores of bone marrow in the heads of long bones in a process known as hematopoiesis. On average, bone marrow constitutes 4% of the total body mass of humans; in an adult having 65 kilograms of mass (143 lbs), bone marrow typically accounts for approximately 2.6 kilograms (5.7 lb). The hematopoietic component of bone marrow produces approximately 500 billion blood cells per day, which use the bone marrow vasculature as a conduit to the body's systemic circulation. Bone marrow is also a key component of the lymphatic system, producing the lymphocytes that support the body's immune system.
Bone marrow transplants can be conducted to treat severe diseases of the bone marrow, including certain forms of cancer such as leukemia. Additionally, bone marrow stem cells have been successfully transformed into functional neural cells, and can also potentially be used to treat illnesses such as inflammatory bowel disease.
Bone marrow (food)
The bone marrow of animals is widely used by humans as food. Marrow is probably the easiest form of offal to obtain, as, being contained in bone, it may be found in any bone-in cut of meat purchased from a butcher or supermarket.
History
Many cultures have used bone marrow as food throughout history. Some anthropologists believe that early humans were scavengers rather than hunters in some regions of the world. Marrow would have been a useful food source (largely due to its fat content) for tool-using hominids, who were able to crack open the bones of carcasses left by apex predators such as lions.
European diners in the 18th century often used a marrow scoop (or marrow spoon), often of silver and with a long, thin bowl, as a table implement for removing marrow from a bone. Bone marrow was also used in various preparations, such as pemmican. Bone marrow's popularity as a food is now relatively limited in the western world, but it remains in use in some gourmet restaurants, and is popular among food enthusiasts.
Podcasts:
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by Protest The Hero
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by Alcoa
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by Mellowdrone
Bone Marrow
by: Protest The HeroThus now he knelt before the ruins,
cold of sweat, heat of flame
to vow the severed heads
Of those who brought the village, the village to its shame.
Those who plundered,pilfered, pillaged lives
would now accept the blame.
He would find them all
with a mighty vengeance paid for in their pain
Shah-jan, the king of kings
wore seven rings and 60 feathers
Plucked from sparrow's wings
Growing fat on the throne,
He sat like a stone.
A man who had never known
No hunger, shown no mercy with
In promises broke like a bone.
And there he sat like a stone,
With promises broke like a bone
Dispersed about the people
rostam calls out for his equals
in third to rise and cast curse
is that the worst of vengeance
enemies they roam the tree's
is that the worst of vengeance
The royalty must die x3
The royalty must die like common beggars and petty thieves x2
Tomorrow they will find us
Oh God x3
Heads of children will roll
Thus know he knelt before the ruins
Cold of sweat, heat of flame
He found the severed heads x2
Of those who brought the village, the village to its shame.
3:16
The king of kings wore
Seven rings and 60 feathers
Plucked from sparrows’ wings.
He’s growing fat, growing fat on the throne
Where he sat like a stone
A man who has never known no hunger
Shown no mercy
Those who ride against us
Will be murdered where they stand
let our arrows rain from sky
To drain the blood into the land
If a mortal stands before us
Strike him down with sleight of hand
And if heaven rides against us the