Blue

Blue is the colour between violet and green on the optical spectrum of visible light. Human eyes perceive blue when observing light with a wavelength between 450 and 495 nanometres. Blues with a higher frequency and thus a shorter wavelength gradually look more violet, while those with a lower frequency and a longer wavelength gradually appear more green. Pure blue, in the middle, has a wavelength of 470 nanometres. In painting and traditional colour theory, blue is one of the three primary colours of pigments, along with red and yellow, which can be mixed to form a wide gamut of colours. Red and blue mixed together form violet, blue and yellow together form green. Blue is also a primary colour in the RGB colour model, used to create all the colours on the screen of a television or computer monitor.

The modern English word blue comes from Middle English bleu or blewe, from the Old French bleu, a word of Germanic origin, related to the Old High German word blao. The clear sky and the deep sea appear blue because of an optical effect known as Rayleigh scattering. When sunlight passes through the atmosphere, the blue wavelengths are scattered more widely by the oxygen and nitrogen molecules, and more blue comes to our eyes. Rayleigh scattering also explains blue eyes; there is no blue pigment in blue eyes. Distant objects appear more blue because of another optical effect called atmospheric perspective.

Blue (Down by Law album)

Blue is the second full-length album by the punk rock band Down by Law.

Track listing

Personnel

Essence (Lucinda Williams album)

Essence is Lucinda Williams' sixth album. It was released in 2001. The album debuted on the Billboard 200 at number 28, selling about 44,500 copies in its first week. According to Billboard as of February 2008, the album had sold 336,000 copies in the U.S.

Reception

Essence was highly anticipated coming after a three-year gap from her lauded Car Wheels on a Gravel Road and the critical reviews reflect that. Although positive, none rate the album as highly as her breakthrough. Robert Christgau, who raved about Car Wheels, called the album "imperfect" but still praised her artistry saying "[she] is too damn good to deny." Reviewers noted the difference in tone between the two albums with Rolling Stone citing the "willful intimacy" of the music while Spin contrasted its "halting, spare" presentation with Car Wheels "giddy, verbose" one. In a review posted by Salon the album was called "an emotional mess of a masterpiece".

Q listed Essence as one of the best 50 albums of 2001.

Onyx (Pop Evil album)

Onyx is a rock opera and the fourth studio album by Pop Evil. It was released on May 14, 2013. The first single, "Trenches", was released February 28, 2013. The album was available for streaming a day before its official release date. It was produced by Johnny K, mixed by Jay Ruston, and mastered by Paul Logus. Additional vocal production was performed by Dave Bassett. Additional programming was done by Bassett and Matt Doughtery.

The album debuted on the Billboard 200 at No. 39, No. 9 on the Independent Albums chart, with 10,000 copies sold in its first week. It has sold 122,000 copies in the United States as of July 2015.

Track listing

Charts

Album

Singles

Band

References

External links

Onyx (group)

Onyx is an American hardcore hip hop group from South Jamaica, Queens, New York. The group is composed of East Coast rappers Sticky Fingaz and Fredro Starr. Sonny Seeza (formerly known as both Suavé and Sonsee) and the late Big DS (Marlon Fletcher) were also members; Big DS left after the group's debut album. Their music has been used in movies such as How High and 8 Mile and TV shows such as The Cleveland Show and Tosh.0 as well as numerous commercials, including SoBe and Gatorade.

History

Early career

The group was formed in 1988 and Onyx released its first 12" single, "Ah, And We Do It Like This", in 1990. The song revealed a strong jazz influence, noticeably more than in their later work. In 1991, Onyx was going to present a demo to Jam Master Jay at Def Jam, but Big DS and Sonee Seeza (then only known as Suavé) were in Connecticut at the time, so Fredro Starr called up his cousin Sticky Fingaz (who lived in Brooklyn). Once Sticky Fingaz joined the group, the group released Throw Ya Gunz in 1992.

Oncolytic adenovirus

Adenovirus varieties have been explored extensively as a viral vector for gene therapy and also as an oncolytic virus.

Of the many different viruses being explored for oncolytic potential, an adenovirus was the first to be approved by a regulatory agency, the genetically modified H101 strain. It gained regulatory approval in 2005 from China's State Food and Drug Administration (SFDA) for the treatment of head and neck cancer.

Engineering of oncolytic adenovirus

Adenoviruses have so far been through three generations of development. Some of the strategies for modification of adenoviruses are described below.

Attenuation

For adenovirus replication to occur, the host cell must be induced into S-phase by viral proteins interfering with cell cycle proteins. The adenoviral E1A gene is responsible for inactivation of several proteins, including retinoblastoma, allowing entry into S-phase. The adenovirus E1B55kDa gene cooperates with another adenoviral product, E4ORF6, to inactivate p53, thus preventing apoptosis. It was initially proposed that an adenovirus mutant lacking the E1B55kDa gene, dl1520 (ONYX-015), could replicate selectively in p53 deficient cells.