Blue

Blue is the colour between violet and green on the optical spectrum of visible light. Human eyes perceive blue when observing light with a wavelength between 450 and 495 nanometres. Blues with a higher frequency and thus a shorter wavelength gradually look more violet, while those with a lower frequency and a longer wavelength gradually appear more green. Pure blue, in the middle, has a wavelength of 470 nanometres. In painting and traditional colour theory, blue is one of the three primary colours of pigments, along with red and yellow, which can be mixed to form a wide gamut of colours. Red and blue mixed together form violet, blue and yellow together form green. Blue is also a primary colour in the RGB colour model, used to create all the colours on the screen of a television or computer monitor.

The modern English word blue comes from Middle English bleu or blewe, from the Old French bleu, a word of Germanic origin, related to the Old High German word blao. The clear sky and the deep sea appear blue because of an optical effect known as Rayleigh scattering. When sunlight passes through the atmosphere, the blue wavelengths are scattered more widely by the oxygen and nitrogen molecules, and more blue comes to our eyes. Rayleigh scattering also explains blue eyes; there is no blue pigment in blue eyes. Distant objects appear more blue because of another optical effect called atmospheric perspective.

Blue (tourism magazine)

Blue was an adventure travel magazine, founded in 1997 by Amy Schrier, with David Carson as the original design consultant. Its focus was on global adventure travel. It was published in New York and is now out of print; its last issue was February–March 2000.

The cover of its first issue was included in a list of the Top 40 magazine covers of the last 40 years by the American Society of Magazine Editors. In 1999 Life magazine listed it in the Best Magazine Photos of the Year. The New York Times characterized it as "not your father's National Geographic."

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Blue Gender

Blue Gender (Japanese: ブルージェンダー, Hepburn: Burū Jendā) is a 26-episode anime created, co-directed and co-written by Ryōsuke Takahashi (of Armored Trooper Votoms and Gasaraki fame) broadcast in Japan from 1999-2000. Blue Gender was created by the Japanese animation studio, AIC and is distributed in the United States by Funimation Entertainment. In 2003, Blue Gender was released on American television as part of Cartoon Network's Adult Swim, though it had originally been planned for Toonami, and was thus edited to remove its graphic violence, nudity, and sex scenes (however, its airing on Colours TV and Funimation Channel in the United States). There is also a compilation movie (Blue Gender: The Warrior) available on DVD with an alternative ending. The series was also shown on the Sci Fi Channel in the UK in 2002-2003. The Blue Gender series is set in the 2030s, in which Earth has been overrun by the Blue, which are mutated insect-like creatures containing a newly evolved B-cell that recently appeared in several humans, including the main protagonist, Yuji Kaido, that kill and harvest humans for food. Most of the surviving human race has moved to Second Earth, a huge space station that orbits the planet. The series mostly focuses on Yuji and Marlene's relationship as they work together to reach Second Earth and their participation in military combat operations against the Blue.

Bag (Bužim)

Bag is a settlement in Bužim, in Bosnia and Herzegovina.

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Coordinates: 44°00′N 18°07′E / 44.000°N 18.117°E / 44.000; 18.117

BAG3

BAG family molecular chaperone regulator 3 is a protein that in humans is encoded by the BAG3 gene. BAG3 is involved in chaperone-assisted selective autophagy (CASA).

Function

BAG proteins compete with Hip-1 for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.

Clinical significance

BAG gene has been implicated in age related neurodegenerative diseases such as Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively. It has also been shown to be the cause of familial dilated cardiomyopathy. That BAG3 mutations are responsible for familial dilated cardiomyopathy is confirmed by another study describing 6 new molecular variants (2 missense and 4 premature Stops ). Moreover, the same publication reported that BAG3 polymorphisms are also associated with sporadic forms of the disease together with HSPB7 locus.

BAG1

BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene.

Function

The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this mRNA through the use of alternative translation initiation sites, including a non-AUG site.

Clinical significance

BAG gene has been implicated in age related neurodegenerative diseases as Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively.

Interactions

BAG1 has been shown to interact with: