Ago

Ago or AGO may refer to:

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Argonaute

The Argonaute protein family plays a central role in RNA silencing processes, as essential catalytic components of the RNA-induced silencing complex (RISC). RISC complex is responsible for the gene silencing phenomenon known as RNA interference (RNAi). Argonaute proteins bind different classes of small non-coding RNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). Small RNAs guide Argonaute proteins to their specific targets through sequence complementarity (base pairing), which then leads to mRNA cleavage or translation inhibition.

Discovery

The RNA interference (RNAi) was first reported in 1995 by Guo and Kemphues, and similar pathways collectively referred to as RNA silencing were discovered in plants and fungi. The beginning of people’s understanding of the mechanism of RNA silencing began only in 1998 with the experiments of Fire and colleagues demonstrating that double-stranded RNA triggered RNAi. RNA silencing pathways process long RNAs into small RNAs that direct the repression of transcription or translation of nucleic acid targets with sequence corresponding to the small RNAs. These single-stranded RNAs, referred to as guide strands, are incorporated into RNA silencing effectors complexes such as the RNA-induced silencing complex (RISC). These RNA silencing effector complexes contain Argonaute family proteins.

Blizzard

A blizzard is a severe snowstorm characterized by strong sustained winds of at least 35 mph (56 km/h) and lasting for a prolonged period of time—typically three hours or more. A ground blizzard is a weather condition where snow is not falling but loose snow on the ground is lifted and blown by strong winds.

Definition

In the United States, the National Weather Service defines a blizzard as a severe snowstorm characterized by strong winds causing blowing snow that results in low visibilities. The difference between a blizzard and a snowstorm is the strength of the wind, not the amount of snow. To be a blizzard, a snow storm must have sustained winds or frequent gusts that are greater than or equal to 56 km/h (35 mph) with blowing or drifting snow which reduces visibility to 400 m or 0.25 mi or less and must last for a prolonged period of time—typically three hours or more.

While severe cold and large amounts of drifting snow may accompany blizzards, they are not required. Blizzards can bring whiteout conditions, and can paralyze regions for days at a time, particularly where snowfall is unusual or rare.

Blizzard (disambiguation)

A blizzard is a severe winter storm condition characterized by low temperatures, strong winds, and heavy snow.

Blizzard or The Blizzard may also refer to:

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Sport

Amateur wrestling

Amateur wrestling is the most widespread form of sport wrestling.. There are two international wrestling styles performed in the Olympic Games under the supervision of United World Wrestling (UWW; formerly known as FILA, from the French acronym for International Federation of Associated Wrestling Styles): Greco-Roman and freestyle. Freestyle is possibly derived from the English Lancashire style. A similar style, commonly called collegiate (also known as scholastic or folkstyle), is practiced in colleges and universities, secondary schools, middle schools, and among younger age groups in the United States. Where the style is not specified, this article refers to the international styles of competition on a mat. In February 2013, the IOC voted to remove the sport from the 2020 Summer Olympics onwards. On 8 September 2013, the IOC announced that wrestling would return to the Summer Olympics in 2020. The rapid rise in the popularity of the combat sport Mixed martial arts (MMA) has increased interest in amateur wrestling due to its effectiveness in the sport and it is considered a core discipline.