The Bankhead Highway was a United States cross-country automobile highway connecting Washington, D.C. and San Diego. It was part of the National Auto Trail system. The road was named for Alabama politician John Hollis Bankhead, a leader in the early national road building movement. In later years, several stretches of U.S. Route 78 in northwest Alabama were renamed for Bankhead's son, former U.S. Representative and Speaker of the House William B. Bankhead.
As was common with early auto trails, the Bankhead Highway had several different routes. The main and branch routes below are considered to be the primary configurations of the highway.
The route began in Washington, D.C., following US 1 into Virginia.
In Virginia, the route followed US 1 through Fredericksburg and Richmond. At South Hill the route turned southwest onto US 58 and followed it to Clarksville, where it turned south onto US 15 and continued into North Carolina.