Mitotic checkpoint serine/threonine-protein kinase BUB1 beta is an enzyme that in humans is encoded by the BUB1B gene.
This gene encodes a kinase involved in spindle checkpoint function and chromosome segregation. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.
Increased expression of BubR1 in mice extends a healthy lifespan.
BUB1B has been shown to interact with:
I just wanna be your ball and chain
Wrapped around your finger
Locked up, tied me down
Follow you forever
Never let you get away,
Holding on like a ball and chain
I never wanted to stay
In one place too long
Oh no, not me, I didn't wanna be
A victim of that fatal touch
When you want someone too much but
You, you'll be the end of me
And I don't want to hurt anymore
I tried my best to avoid
Making promises
Oh, no, not me, I didn't wanna
be a prisoner of that tender trap
When there's no turning back but
You, you got me on my knees
And I won't be afraid anymore
I just wanna be your ball and chain
Wrapped around your finger
Locked up, tied me down
Follow you forever
Never let you get away,
Holding on like a ball and chain
I know it's been some time confined to be alone
but I know I found the one who's gotts be this love jones
you know that I get open when you rubbing my back the goose bumps
and chills must be proof of that cos I'm feeling when your dealing
all the knowledge you've got about making it good
when your touching my spots I've goy lots of loving
when we bubbling it right I look forward to the time the day turns night
you've gotta meet me at the crib for the quarter to nine
and at the time love devine and what do I find
I won't be afraid anymore
The side of you be wanting me just haunting my fight boy be my ball and chain yo it's gotta be right
I just wanna be your ball and chain
Wrapped around your finger
Locked up, tied me down
Follow you forever
Never let you get away,