BTG2
Protein BTG2 also known as BTG family member 2 or NGF-inducible anti-proliferative protein PC3 or NGF-inducible protein TIS21, is a protein that in humans is encoded by the BTG2 gene (B-cell translocation gene 2) and in other mammals by the homologous Btg2 gene. This protein controls cell cycle progression and proneural genes expression by acting as a transcription coregulator that enhances or inhibits the activity of transcription factors.
The protein BTG2 is the human homolog of the PC3 (pheochromocytoma cell 3) protein in rat and of the Tis21 (tetradecanoyl phorbol acetate-inducible sequence 21) protein in mouse.Tis21 had been originally isolated as a sequence induced by TPA in mouse fibroblasts, whereas PC3 was originally isolated as sequence induced at the beginning of neuron differentiation;BTG2 was then isolated in human cells as sequence induced by p53 and DNA damage.
The protein encoded by the gene BTG2 (which is the official name assigned to the gene PC3/Tis21/BTG2) is a member of the BTG/Tob family (that comprises six proteins BTG1, BTG2/PC3/Tis21, BTG3/ANA, BTG4/PC3B, Tob1/Tob and Tob2). This family has structurally related proteins that appear to have antiproliferative properties. In particular, the BTG2 protein has been shown to negatively control a cell cycle checkpoint at the G1 to S phase transition in fibroblasts and neuronal cells by direct inhibition of the activity of cyclin D1 promoter.
Podcasts:
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by Self
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by Three Degrees
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by Yg
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by Kuraia
Pattycake
by: Selfso they sucked the life out of you
so now what the hell do you do
so your train went off of it's track
back when michael jackson was black
what ya gonna prove
how you gonna prove it
there's no need to waste your life
shatter and abuse it, babe
i'm talking about a time when a dimebag was a dime
no need to dwell upon the here and now, baby
- chorus -
let's pretend it's 1978; we're playing patty cake and baker's men
let's pretend the popsicles we ate all gave us stomach aches on our neighbor's lawn
so you called the chief of police
(this is the pig, this is the pig)
and told him what to do
call the zoo and the justice of peace
and told them what to do
sold your house alone
told your boss to screw it
bought a time machine
grab the wheel and do it, baby
back unto a time when a dimebag was a dime
no need to spend another moment here, baby
* repeat chorus *
hello operator please give me number nine
and if you disconnect me I'll kick your fat
behind the refrigerator there was a piece of glass
miss suzy sat upon it and broke her little
ask me no more questions, i'll tell you no more lies
the boys are in the bathroom zipping up their
flies are in the city and bee stings are our crutch
the boys and girls are necking and asking you just
what ya gonna prove
how you gonna prove it
there's no need to waste your life
shatter and abuse it, babe
i'm talking about a time when a dimebag was a dime
no need to dwell upon the here and now, baby