BTG1
Protein BTG1 is a protein that in humans is encoded by the BTG1 gene.
Function
The BTG1 gene locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. It is a member of a family of antiproliferative genes. BTG1 expression is maximal in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. It negatively regulates cell proliferation.
Interactions
BTG1 has been shown to interact with:
Clinical relevance
Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.
Maintenance of adult neural stem cells
Recent data, obtained in a new model of mouse lacking the BTG1 gene, indicate that BTG1 is essential for the proliferation and expansion of stem cells in the adult neurogenic niches, i.e. the dentate gyrus and subventricular zone. In particular, BTG1 keeps adult neural stem cells in quiescence, preserving the neural stem cells pool from depletion; in fact, in absence of BTG1, the stem and progenitor cells initially hyper proliferate and then in the longer period lose the ability to proliferate and expand (; see for review:). Other recent data indicate that physical exercise can fully reconstitute the proliferative defect of stem cells that follows the ablation of the BTG1 gene, suggesting that the pool of neural stem cells maintains a hidden form of plasticity which is tightly controlled by BTG1; hence, BTG1 might prevent the depletion of stem cells in the presence of strong neurogenic stimuli or of neural degenerative stimuli.
Podcasts:
-
by Self
-
by Three Degrees
-
by Yg
-
by Kuraia
Pattycake
by: Selfso they sucked the life out of you
so now what the hell do you do
so your train went off of it's track
back when michael jackson was black
what ya gonna prove
how you gonna prove it
there's no need to waste your life
shatter and abuse it, babe
i'm talking about a time when a dimebag was a dime
no need to dwell upon the here and now, baby
- chorus -
let's pretend it's 1978; we're playing patty cake and baker's men
let's pretend the popsicles we ate all gave us stomach aches on our neighbor's lawn
so you called the chief of police
(this is the pig, this is the pig)
and told him what to do
call the zoo and the justice of peace
and told them what to do
sold your house alone
told your boss to screw it
bought a time machine
grab the wheel and do it, baby
back unto a time when a dimebag was a dime
no need to spend another moment here, baby
* repeat chorus *
hello operator please give me number nine
and if you disconnect me I'll kick your fat
behind the refrigerator there was a piece of glass
miss suzy sat upon it and broke her little
ask me no more questions, i'll tell you no more lies
the boys are in the bathroom zipping up their
flies are in the city and bee stings are our crutch
the boys and girls are necking and asking you just
what ya gonna prove
how you gonna prove it
there's no need to waste your life
shatter and abuse it, babe
i'm talking about a time when a dimebag was a dime
no need to dwell upon the here and now, baby