ABCB11
ATP-binding cassette, sub-family B member 11 also known as ABCB11 is a protein which in humans is encoded by the ABCB11 gene.
Function
The product of the ABCB11 gene is an ABC transporter named BSEP (Bile Salt Export Pump), or sPgp (sister of P-glycoprotein). This membrane-associated protein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is a member of the MDR/TAP subfamily. Some members of the MDR/TAP subfamily are involved in multidrug resistance. This particular protein is responsible for the transport of taurocholate and other cholate conjugates from hepatocytes (liver cells) to the bile. In humans, the activity of this transporter is the major determinant of bile formation and bile flow.
Clinical significance
ABCB11 is a gene associated with progressive familial intrahepatic cholestasis type 2 (PFIC2). PFIC2 caused by mutations in the ABCB11 gene increases the risk of hepatocellular carcinoma in early life.
Podcasts:
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by Busy P
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by Busy P
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by Busy Bee
To Protect And Entertain (feat. Murs)
by: Busy PL.A., city of smog
Scenesters, hipsters, sneakers, blogs
I got the flyer from Amoeba Records
I called up P and I said, "Yo, let's check this"
I heard at these rave-things, chicks get naked
And I got a dick that's as big as Texas
?? arrived from the crew LA DAFT
I said it's my first rave, they just laughed
Picked up P from the Magic Castle
And hit up LAX and got in, no hassle
We left there when we hit up centerspace
Ron got his camera all up in my face
Tomorrow morning, I'ma be on Cobrasnake
Making out with a chick that my girlfriend hates
But who cares, the party's downtown
??, we're leaving right now
To protect and entertain
In party we trust
Them other DJs ain't fuckin' with us
And from Paris to L.A.
In cash we trust
It's Murs and Busy P, they ain't fuckin' with us
To protect and entertain
In party we trust
Them other DJs ain't fuckin' with us
And from Paris to L.A.
In cash we trust
It's Murs and Busy P, they ain't fuckin' with us
To protect and entertain
In party we trust
Them other DJs ain't fuckin' with us
And from Paris to L.A.
In cash we trust
It's Murs and Busy P, motherfucker!
In the middle of the dancefloor, so damn crunk
I see the Goldenvoice crew and they so damn drunk
Lindsey, Donna, my man Paul T!
Stacy and they all doin' shots with P
Me, I just saw my future wife walk past me
Singing that Peaches--damn she nasty
DJ AM, Steve Aoki
Got the dancefloor packed and it's mostly
Girls, girls, every day
From Paris to Canada to U.S.A.
I snatched one up and we danced for hours
She talked too much; she was off that powder
But looked so good in her Jeremy Scott
And her looks looked perfect for my copping lot
She put her hand down my pants
So I said, "Later P, I'll see you in France"
To protect and entertain
In party we trust
Them other DJs ain't fuckin' with us
And from Paris to L.A.
In cash we trust
It's Murs and Busy P, they ain't fuckin' with us
To protect and entertain
In party we trust
Them other DJs ain't fuckin' with us
And from Paris to L.A.
In cash we trust
It's Murs and Busy P, they ain't fuckin' with us
To protect and entertain
In party we trust
Them other DJs ain't fuckin' with us
And from Paris to L.A.
In cash we trust
It's Murs and Busy P, motherfucker!
Paris to Los Angeles
Au revoir, motherfuckers
And you can fuck with my accent all you want
But you can suck my dick
And shoutout to all the--all my, all my n-words
All my black people in France
For being the only other niggas to burn some shit down
when the white people fuck wit you
We don't take any shit
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