Band 3

Band 3 anion transport protein also known as anion exchanger 1 (AE1) or band 3 or solute carrier family 4 member 1 (SLC4A1) is a protein that in humans is encoded by the SLC4A1 gene.

Band 3 anion transport protein is a phylogenetically preserved transport protein responsible for mediating the exchange of chloride (Cl⁻) for bicarbonate (HCO₃⁻) across a plasma membrane. Functionally similar members of the AE clade are AE2 and AE3.

Function

This is present in the α-intercalated cells of the collecting ducts of the nephron. these are the main acid secreting cells of the kidney. They generate hydrogen ions and bicarbonate ions from carbon dioxide and water - a reaction catalysed by Carbonic anhydrase. The hydrogen ions are pumped into the collecting duct tubule by vacuolar H⁺ ATPase, the apical proton pump, which thus excretes acid into the urine. kAE1 exchanges bicarbonate for chloride on the basolateral surface, essentially returning bicarbonate to the blood. Here it performs two functions:

BND

BND may stand for:

No Doubt (No Doubt album)

No Doubt is the self-titled debut studio album by the American rock band No Doubt, released March 17, 1992 on Interscope Records. The album was originally recorded as an independent release, but was re-recorded after the band was signed to Interscope. It was produced by Dito Godwin and recorded in a recording studio in Los Angeles.

The album was released during a period in which the United States was mainly focused on grunge music, an angst-ridden genre that was almost the complete opposite of No Doubt's upbeat commercial sound. Despite strong tours, the album failed to perform as well as the record company expected it to, selling only 30,000 copies. The record company refused to fund the release of a single from it, so No Doubt released the album's only single, "Trapped in a Box", independently. Since the band signed out of Interscope, the band independently produced and released a follow-up to No Doubt, The Beacon Street Collection, in 1995. This album had a better commercial performance than the band's debut album, selling 100,000 copies, leading Interscope to finance and support their third album, Tragic Kingdom.