BMP2
BMP2 or BMP-2 may refer to:
See also
Bone morphogenetic protein 2
Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins.
Function
BMP-2 like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. It is involved in the hedgehog pathway, TGF beta signaling pathway, and in cytokine-cytokine receptor interaction. It is involved also in cardiac cell differentiation and epithelial to mesenchymal transition.
BMP-2 and BMP-7 are osteoinductive BMPs: they have been demonstrated to potently induce osteoblast differentiation in a variety of cell types.
Interactions
Bone morphogenetic protein 2 has been shown to interact with BMPR1A.
Clinical use and complications
Bone morphogenetic protein 2 is shown to stimulate the production of bone.Recombinant human protein (rhBMP-2) is currently available for orthopaedic usage in the United States. Implantation of BMP-2 in a collagen sponge induces new bone formation and can be used for the treatment of bony defects, delayed union, and non-union.
Podcasts:
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by Bimbo Boy
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by Bimbo Boy
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