Bleomycin hydrolase

PDB rendering based on 1cb5.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols BLMH; BH; BMH
External IDs OMIM: 602403 MGI: 1345186 HomoloGene: 330 GeneCards: BLMH Gene
EC number 3.4.22.40
RNA expression pattern
PBB GE BLMH 202179 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 642 104184
Ensembl ENSG00000108578 ENSMUSG00000020840
UniProt Q13867 Q8R016
RefSeq (mRNA) NM_000386.3 NM_178645.4
RefSeq (protein) NP_000377.1 NP_848760.1
Location (UCSC) Chr 17:
28.58 – 28.62 Mb		 Chr 11:
76.92 – 76.99 Mb
PubMed search [1] [2]
This box:

Bleomycin hydrolase is an enzyme that in humans is encoded by the BLMH gene.[1][2][3]

Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily.[3]

Interactions [link]

BLMH has been shown to interact with RPL29,[4] RPL11,[4] UBE2I[5] and Amyloid precursor protein.[6]

References [link]

  1. ^ Ferrando AA, Pendas AM, Llano E, Velasco G, Lidereau R, Lopez-Otin C (January 1998). "Gene characterization, promoter analysis, and chromosomal localization of human bleomycin hydrolase". J Biol Chem 272 (52): 33298–304. doi:10.1074/jbc.272.52.33298. PMID 9407121.
  2. ^ Montoya SE, Ferrell RE, Lazo JS (October 1997). "Genomic structure and genetic mapping of the human neutral cysteine protease bleomycin hydrolase". Cancer Res 57 (19): 4191–5. PMID 9331073.
  3. ^ a b "Entrez Gene: BLMH bleomycin hydrolase". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=642.
  4. ^ a b Koldamova, R P; Lefterov I M, DiSabella M T, Almonte C, Watkins S C, Lazo J S (June 1999). "Human bleomycin hydrolase binds ribosomal proteins". Biochemistry (UNITED STATES) 38 (22): 7111–7. doi:10.1021/bi990135l. ISSN 0006-2960. PMID 10353821.
  5. ^ Koldamova, R P; Lefterov I M, DiSabella M T, Lazo J S (December 1998). "An evolutionarily conserved cysteine protease, human bleomycin hydrolase, binds to the human homologue of ubiquitin-conjugating enzyme 9". Mol. Pharmacol. (UNITED STATES) 54 (6): 954–61. ISSN 0026-895X. PMID 9855622.
  6. ^ Lefterov, I M; Koldamova R P, Lazo J S (September 2000). "Human bleomycin hydrolase regulates the secretion of amyloid precursor protein". FASEB J. (UNITED STATES) 14 (12): 1837–47. doi:10.1096/fj.99-0938com. ISSN 0892-6638. PMID 10973933.

Further reading [link]

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Ferrando AA, Velasco G, Campo E, Lopez-Otin C (1996). "Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance.". Cancer Res. 56 (8): 1746–50. PMID 8620487.
  • Brömme D, Rossi AB, Smeekens SP, et al. (1996). "Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization.". Biochemistry 35 (21): 6706–14. doi:10.1021/bi960092y. PMID 8639621.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Koldamova RP, Lefterov IM, Gadjeva VG, Lazo JS (1998). "Essential binding and functional domains of human bleomycin hydrolase.". Biochemistry 37 (8): 2282–90. doi:10.1021/bi9722204. PMID 9485374.
  • Montoya SE, Aston CE, DeKosky ST, et al. (1998). "Bleomycin hydrolase is associated with risk of sporadic Alzheimer's disease.". Nat. Genet. 18 (3): 211–2. doi:10.1038/ng0398-211. PMID 9500538.
  • Zheng W, Johnston SA, Joshua-Tor L (1998). "The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase.". Cell 93 (1): 103–9. doi:10.1016/S0092-8674(00)81150-2. PMID 9546396.
  • Koldamova RP, Lefterov IM, DiSabella MT, Lazo JS (1999). "An evolutionarily conserved cysteine protease, human bleomycin hydrolase, binds to the human homologue of ubiquitin-conjugating enzyme 9.". Mol. Pharmacol. 54 (6): 954–61. PMID 9855622.
  • Takeda A, Nonaka M, Ishikawa A, Higuchi D (1999). "Immunohistochemical localization of the neutral cysteine protease bleomycin hydrolase in human skin.". Arch. Dermatol. Res. 291 (4): 238–40. doi:10.1007/s004030050400. PMID 10335922.
  • Koldamova RP, Lefterov IM, DiSabella MT, et al. (1999). "Human bleomycin hydrolase binds ribosomal proteins.". Biochemistry 38 (22): 7111–7. doi:10.1021/bi990135l. PMID 10353821.
  • O'Farrell PA, Gonzalez F, Zheng W, et al. (1999). "Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease.". Structure 7 (6): 619–27. doi:10.1016/S0969-2126(99)80083-5. PMID 10404591.
  • Malherbe P, Faull RL, Richards JG (2000). "Regional and cellular distribution of bleomycin hydrolase mRNA in human brain: comparison between Alzheimer's diseased and control brains.". Neurosci. Lett. 281 (1): 37–40. doi:10.1016/S0304-3940(00)00802-8. PMID 10686410.
  • Lefterov IM, Koldamova RP, Lazo JS (2000). "Human bleomycin hydrolase regulates the secretion of amyloid precursor protein.". FASEB J. 14 (12): 1837–47. doi:10.1096/fj.99-0938com. PMID 10973933.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.
  • Nivet-Antoine V, Coulhon MP, Le Denmat C, et al. (2003). "[Apolipoprotein E and bleomycin hydrolase. Polymorphisms: association with neurodegenerative diseases]". Ann. Biol. Clin. (Paris) 61 (1): 61–7. PMID 12604387.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.



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