BCR (gene)

The breakpoint cluster region protein (BCR) also known as renal carcinoma antigen NY-REN-26 is a protein that in humans is encoded by the BCR gene. BCR is one of the two genes in the BCR-ABL complex, which is associated with the Philadelphia chromosome. Two transcript variants encoding different isoforms have been found for this gene.

Function

Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for RAC1 and CDC42.

Clinical significance

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein that is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint.

Structure

The Bcr-Abl oncoprotein oligomerisation domain found at the N-terminus of BCR is essential for the oncogenicity of the BCR-ABL fusion protein. The Bcr-Abl oncoprotein oligomerisation domain consists of a short N-terminal helix (alpha-1), a flexible loop and a long C-terminal helix (alpha-2). Together these form an N-shaped structure, with the loop allowing the two helices to assume a parallel orientation. The monomeric domains associate into a dimer through the formation of an antiparallel coiled coil between the alpha-2 helices and domain swapping of two alpha-1 helices, where one alpha-1 helix swings back and packs against the alpha-2 helix from the second monomer. Two dimers then associate into a tetramer.

Gene

A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as the gene–environment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life.

Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotype traits. Colloquial usage of the term "having a gene" (e.g., "good genes," "hair colour gene") typically refers to having a different allele of the gene. Genes evolve due to natural selection or survival of the fittest of the alleles.

Eugene (given name)

Eugene is a common (masculine) first name that comes from the Greek εὐγενής (eugenēs), "noble", literally "well-born", from εὖ (eu), "well" and γένος (genos), "race, stock, kin".Gene is a common shortened form. The feminine variant is Eugenia or Eugénie.

Male foreign-language variants include:

Notable people

Christianity

Military

Gene (novel)

Gene is a thriller novel by Stel Pavlou (born 1970), published in 2005 in England by Simon & Schuster. It is published in several languages with some title changes. The Italian edition has the title La Conspirazione del Minotauro (The Minotaur Conspiracy). The novel is about a fictional New York detective, James North, who in the process of hunting down a criminal, uncovers a genetics experiment to unlock past lives through genetic memory, therefore achieving a kind of immortality. In so doing North discovers his own origins, that of a soldier from the Trojan War who is reincarnated seven times through history, forced to confront his nemesis each time, all for the loss of his one true love.

Characters

Cyclades (born circa 1300 BC)

Incarnations of Cyclades

Athanatos (born circa 1500 BC)

Incarnations of Athanatos

BCR

BCR may refer to:

Organisations

Transport

Radio

Science and Technology

2BACR

2BACR (ACMA callsign: 2BCR) is a community radio station broadcasting on 100.9FM from Bankstown, New South Wales.

History

As 2BCR

The Bankstown City Radio Co-operative was one of the first groups to receive a community radio broadcasting licence. Awarded the licence in 1983, the station began broadcasting as 2BCR from studios in a building at the former site of Georges Hall Public School in Birdwood Avenue, Georges Hall. Its programming included music and community interest programmes including weekend sports shows, youth-oriented request programmes, religious programming and for many years hosted a weekly police round-up. In the mid-90s, the station had a media booth at Belmore Oval to enable live broadcasts of home games by the Bulldogs rugby league team. A mobile studio allowed the station to broadcast from local events. Brendan "Jonesy" Jones got his start at 2BCR, when it was at Georges hall, He famously got his fathers car bogged on the oval after his shift "Jazz beat". Jones now works on Breakfast radio as the Jonesy part of Jonesy and Amanda on WSFM.

Belfast Community Radio

Belfast Community Radio or BCR, was a radio station that broadcast to Belfast between 1990 and 1996. The station broadcast from the basement of Russell Court Complex on Belfast's Lisburn Road. It was replaced by Belfast CityBeat.

History

BCR was launched at 7:30 a.m. on 6 April 1990 with Rick Nugent who was the first presenter, the first song was "Feet of a Dancer" by Maira O'Connell.

In 1992, in attempt to boost audience the station adopted a 'Classic Hits Format' and became known as Classic Trax BCR but by 1994 had reverted to 96.7 BCR.

In 1995, the word 'community' in the title was replaced for 'city' in a further attempt to distance the station from its community roots which had failed to interest audience.

During its final month on air the station simply became known as 96.7FM.

BCR struggled to establish a listener base and was eventually relaunched as Belfast CityBeat in 1996. In contrast with its forerunner, Citybeat became a huge success and is now one of the most popular stations in Northern Ireland.