BCL3

B-cell lymphoma 3-encoded protein is a protein that in humans is encoded by the BCL3 gene.

This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional coactivator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.

Like BCL2, BCL5, BCL6, BCL7A, BCL9, and BCL10, it has clinical significance in lymphoma.

Interactions

BCL3 has been shown to interact with:

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Boron trichloride

Boron trichloride is the inorganic compound with the formula BCl₃. This colorless gas is a valuable reagent in organic synthesis. It is highly reactive toward water.

Production and structure

Boron reacts with halogens to give the corresponding trihalides. Boron trichloride is, however, produced industrially by direct chlorination of boron oxide and carbon at 500 °C.

The carbothermic reaction is analogous to the Kroll process for the conversion of titanium dioxide to titanium tetrachloride. In the laboratory BF₃ reacted with AlCl₃ gives BCl₃ via halogen exchange. BCl₃ is a trigonal planar molecule like the other boron trihalides, and has a bond length of 175pm.

A degree of π-bonding has been proposed to explain the short B− Cl distance although there is some debate as to its extent. It does not dimerize, although NMR studies of mixtures of boron trihalides shows the presence of mixed halides. The absence of dimerisation contrasts with the tendencies of AlCl₃ and GaCl₃, which form dimers or polymers with 4 or 6 coordinate metal centres.