BCL11B

B-cell lymphoma/leukemia 11B is a protein that in humans is encoded by the BCL11B gene.

Function

This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. The specific function of this gene has not yet been determined, but it could also be involved in some malignancies. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported.

Recent research suggests that BCL11B is crucial for ameloblasts (the cells that produce tooth enamel) to form and work properly.

Interactions

BCL11B has been shown to interact with COUP-TFI.

References

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.