Bcl-2 homologous antagonist/killer is a protein that in humans is encoded by the BAK1 gene on chromosome 6. The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
BAK1 is a pro-apoptotic Bcl-2 protein containing four Bcl-2 homology (BH) domains: BH1, BH2, BH3, and BH4. These domains are composed of nine α-helices, with a hydrophobic α-helix core surrounded by amphipathic helices and a transmembrane C-terminal α-helix anchored to the mitochondrial outer membrane (MOM). A hydrophobic groove formed along the C-terminal of α2 to the N-terminal of α5, and some residues from α8, binds the BH3 domain of other BCL-2 proteins in its active form.
Sometimes I feel so lost S.O.S. all my lines are crossed. I bite off more than I can chew. It's killing me its killing you there's nothing that I'd rather do. It's got me now its holding me. A sign of something good a sign I thought I'd never see. I try to keep it in my head. We'll you can kick my ass and burn your books, but it won't change a word I've said. I guess I should have seen it coming. It's in the smile on his face. Did you really think that this would be so easy? I think you made a big mistake. What went so wrong? Every action has reaction in this fucked up world that you created. Now you're head is so full of negativity and shattered dreams. A world of noise you end up hating. It's got me now it's holding me. A sign of something good a sign I thought I'd never see. I try to keep it in my head. We'll you can kick my ass and burn you're books but it won't change a word I've said. I guess I should have seen it coming. It's in the smile on his face. Did you really think that this would be so easy? I think you made a big mistake. What went so wrong it's been too long. So just take it on the chin. It's who you are and what you do. Not who you were or what you have been. There's just one thing you should know. That I still care to work it out don't think about it let it go.