BAG1

BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene.

Function

The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this mRNA through the use of alternative translation initiation sites, including a non-AUG site.

Clinical significance

BAG gene has been implicated in age related neurodegenerative diseases as Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively.

Interactions

BAG1 has been shown to interact with:

  • Androgen receptor,
  • C-Raf,
  • Calcitriol receptor,
  • Glucocorticoid receptor,
  • HSPA8,
  • HBEGF,
  • PPP1R15A,
  • NR1B1, and
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