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Bace
Bace is a village in the municipality of Prokuplje, Serbia. According to the 2002 census, the village has a population of 284 people.
References
Coordinates: 43°13′13″N 21°20′43″E / 43.22028°N 21.34528°E / 43.22028; 21.34528
Beta-secretase 1
Beta-secretase 1 (BACE1), also known as beta-site amyloid precursor protein cleaving enzyme 1, beta-site APP cleaving enzyme 1, membrane-associated aspartic protease 2, memapsin-2, aspartyl protease 2, and ASP2, is an enzyme that in humans is encoded by the BACE1 gene.
BACE1 is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. The transmembrane protein contains two active site aspartate residues in its extracellular protein domain and may function as a dimer.
Role in Alzheimer's disease
Generation of the 40 or 42 amino acid-long amyloid-β peptides that aggregate in the brain of Alzheimer's patients requires two sequential cleavages of the amyloid precursor protein (APP). Extracellular cleavage of APP by BACE1 creates a soluble extracellular fragment and a cell membrane-bound fragment referred to as C99. Cleavage of C99 within its transmembrane domain by γ-secretase releases the intracellular domain of APP and produces amyloid-β. Since alpha-secretase cleaves APP closer to the cell membrane than BACE1 does, it removes a fragment of the amyloid-β peptide. Initial cleavage of APP by alpha-secretase rather than BACE1 prevents eventual generation of amyloid-β.
Beta-secretase 2
Beta-secretase 2 is an enzyme that in humans is encoded by the BACE2 gene.
BACE2 is a close homolog of BACE1, a protease known to be an important enzyme involved in the cellular pathways that some believe lead to Alzheimer's disease. The physiological function and role of BACE2 in Alzheimer's disease is unknown.
Function
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene. It has been reported that BACE2 is the main protease that mediates the release of the amyloidogenic ectodomain of Pmel17 in melanocytes.
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Bace
ALBUMS
- Unravelled released: 2006
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by 504 Boyz
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by 504 Boyz
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by 504 Boyz
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by 504 Boyz
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by 504 Boyz
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by 504 Boyz
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by 504 Boyz
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by 504 Boyz
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by 504 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 69 Boyz
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by 3 Piece
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by 3 Piece
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by 3 Piece
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by 3 Piece
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by 3 Piece
Holla
by: 504 Boyz[Chorus]: Master P {Choppa}
Them boys on that block holla (ooh ooh)
Them girls that got it hot holla (ooh ooh)
If ya runnin' from them cops holla (ooh ooh)
{Holla...} (ooh ooh) {Holla} (ooh ooh)
[Verse 1]: Master P
Call me trashman cuz I put it up and back
Whodi owe me money I'ma bust his fuckin' ass
I'm allergic to Dr. Pepper, so pass me Dr. Cristale
Hit me on the two-way, whodi, I get wit'cha
Put it on the stove, bake it like a pie
Take it to the hood, slang it 16-5
When niggas snort it boy, they be passin' it to they girls
Wrap it up in Ziploc, back it up and twirl
Send money to the pent. Mac and C be home soon
Bitches start snitchin' I'ma send 'em to the moon
I could sell a hoe a green, front a hustler a lake
I could never fall off, I'm the "Ghetto Bill" Gates
[Chorus]
[Verse 2]: Curren$y
These lil' niggas can't take it anymore
I push through the club iced out, low key with my P. Miller galore
Hoes breakin' down the doors, uhh
Because the 504 Boyz here they can't wait 'til we get on
It's Curren$y the motherfuckin' rookie of the year
This ain't the WNBA, ain't no pussies over here
Yeah, I'm makin' figures fuckin' with the Ghetto Bill
And a truck with some rims that's bigger than Ferris wheels, holla
[Chorus]
[Verse 3]: Krazy
See this No Limit army nigga, that's my Kliq
The hoe that you tongue kissin' used to be my bitch
For these sayin' they'll slay a nigga, they called pricks
And this brown shit I'm sniffin' nigga, it got me sick
And this big truck I'm pushin', nigga, my tight whip
With a chop of lead on the seat, that'll make you flip
My alias, believe me, Doc Holliday
If it's beef, I'm like AIDS, I'll never go away
[Chorus]
[Verse 4]: Master P
I might be something sly but I won't forget
Tell Double X-L they can, suck my dick
I might be country but I'm ghetto rich
And when it comes to grindin', I started this shit
I put the G in Ghetto, nigga, call me Ghetto Fab
Started with some quarters then I flipped it to some halves
Put the Coke in Coca-Cola, no baking soda
Call me Pistol P, cuz I slang them granola's
[Chorus]
[Verse 5]: T-Bo
I guess them thangs just got dropped off, the block's hot like hot sauce
Some cop cars keep passin' I promise y'all they not lost
Convicted felons noticed when they tryin' to knock ya socks off
Go braggin' to them hatin' bitches, find how much ya watch cost
Loose lips, sank ships, bitch, so watch what you sayin'
It's the New No Limit, baby, got us under surveillance
And the Feds ain't playin' they kickin' down doors daily
Ain't this a bitch, I just got off probation
[Chorus]
[Verse 6]: Magic
I'm tryin' to get me a whole chicken (chop it down for the dimes)
Then flip that bitch quicker than I (flip these rhymes)
Now I'm on two birds I'ma flip (one more time)
And I'ma cop the bitch you left behind
(I'm tryin', I'm hustlin') don't trust me when I'm broke
And I don't discriminate I want the money and a goat
Yeah, better hope I wait, I'm ass out (things will get bloody)
(Four to ya tummy, real messy and ugly)
[Chorus]
[Outro]: Master P
If ya East Coast thuggin, holla (ooh ooh)
If ya West Coast thuggin, holla (ooh ooh)
If ya Midwest thuggin' holla (ooh ooh)
If ya Down South hustlin' holla (ooh ooh)
Latest News for: bace
Charlotte company moving to York County will bring 160 jobs, $11.5 million investment
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