ATN

ATN is the Sydney flagship television station of the Seven Network in Australia. The licence, issued to a company named Amalgamated Television Services, a subsidiary of Fairfax, was one of the first four licences (two in Sydney, two in Melbourne) to be issued for commercial television stations in Australia. It began broadcasting on 2 December 1956.

The station formed an affiliation with GTV-9 Melbourne in 1957, in order to share content. In 1963, Frank Packer ended up owning both GTV-9 and TCN-9, so as a result the stations switched their previous affiliations. ATN-7 and HSV-7 joined to create the Australian Television Network, which later became the Seven Network. ATN-7 is the home of the national level Seven News bulletins.

The studios and transmission tower

The station opened in 1956 with principal offices and studios located at Mobbs Lane, Epping (a suburb about 18 kilometres north west of Sydney). The initial black and white cameras and other equipment was supplied by the Marconi Company of England. Conversion to PAL colour occurred on 1 March 1975. Digital DVB-T commenced on 1 January 2001.

ATN1

Atrophin-1 is a protein that in humans is encoded by the ATN1 gene. It is expressed in nervous tissue.

Function

Dentatorubral pallidoluysian atrophy is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion of a trinucleotide repeat within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein.

Clinical significance

Mutations in ATN1 are associated with a form of trinucleotide repeat disorder known as "dentatorubral-pallidoluysian atrophy" or "dentatorubropallidoluysian atrophy".

Interactions

ATN1 has been shown to interact with:

References

Further reading

External links

Bis-choline tetrathiomolybdate

Bis-choline tetrathiomolybdate, or WTX101, is a salt of tetrathiomolybdate (TTM, MoS₄²⁻) and choline currently under investigation as a therapy against Wilson's disease, a rare and potentially fatal disease in which the body cannot regulate copper. Wilson disease is an autosomal recessive genetic disorder that is manifested by serious hepatic, neurologic or psychiatric symptoms. The disease is fatal if left undiagnosed and untreated. It is estimated that approximately 1 individual in every 15,000 worldwide have Wilson's disease, corresponding to approximately 30,000 individuals in the European Union and approximately 20,000 in the United States.

Bis-choline tetrathiomolybdate has been evaluated in clinical trials in patients with various forms of cancer and has received orphan designation in the US and EU as a potential therapy against Wilson disease.

Bis-choline salt of tetrathiomolybdate is a de-coppering therapy in clinical development against Wilson disease under the code name WTX101 by Wilson Therapeutics AB. Wilson Therapeutics was founded by HealthCap in 2012.

Aztec

The Aztec /ˈæztɛk/ people were certain ethnic groups of central Mexico, particularly those groups who spoke the Nahuatl language and who dominated large parts of Mesoamerica from the 14th to 16th centuries. The Nahuatl words aztecatl [asˈtekat͡ɬ] (singular) and aztecah [asˈtekaʔ] (plural) mean "people from Aztlan", a mythological place for the Nahuatl-speaking culture of the time, and later adopted as the word to define the Mexica people. Often the term "Aztec" refers exclusively to the Mexica people of Tenochtitlan (now the location of Mexico City), situated on an island in Lake Texcoco, who referred to themselves as Mēxihcah Tenochcah [meːˈʃiʔkaʔ teˈnot͡ʃkaʔ] or Cōlhuah Mexihcah [ˈkoːlwaʔ meːˈʃiʔkaʔ].

Sometimes the term also includes the inhabitants of Tenochtitlan's two principal allied city-states, the Acolhuas of Texcoco and the Tepanecs of Tlacopan, who together with the Mexica formed the Aztec Triple Alliance which controlled what is often known as the "Aztec Empire". In other contexts, Aztec may refer to all the various city states and their peoples, who shared large parts of their ethnic history and cultural traits with the Mexica, Acolhua and Tepanecs, and who often also used the Nahuatl language as a lingua franca. In this meaning it is possible to talk about an Aztec civilization including all the particular cultural patterns common for most of the peoples inhabiting Central Mexico in the late postclassic period.

Aztec (disambiguation)

Aztec or Aztek may mean:

Aztec or Aztek may also refer to:

Brands and products

Computing

Entertainment and media

Organizations and orders

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Nahuatl

Nahuatl (/ˈnɑːwɑːtəl/;Nahuatl pronunciation: [ˈnaːwatɬ]), known informally as Aztec, is a language or group of languages of the Uto-Aztecan language family. Varieties of Nahuatl are spoken by an estimated 1.5 million Nahua people, most of whom live in Central Mexico. All Nahuan languages are indigenous to Mesoamerica.

Nahuatl has been spoken in Central Mexico since at least the 7th century CE. It was the language of the Aztecs who dominated what is now central Mexico during the Late Postclassic period of Mesoamerican history. During the centuries preceding the Spanish conquest of Mexico, the Aztec Empire had expanded to incorporate a large part of central Mexico, and its influence caused the variety of Nahuatl spoken by the residents of Tenochtitlan to become a prestige language in Mesoamerica. At the conquest, with the introduction of the Latin alphabet, Nahuatl also became a literary language, and many chronicles, grammars, works of poetry, administrative documents and codices were written in it during the 16th and 17th centuries. This early literary language based on the Tenochtitlan variety has been labeled Classical Nahuatl and is among the most studied and best-documented languages of America.