Azapirones are a class of drugs used as anxiolytics and antipsychotics. They are commonly employed to add on antidepressants, such as selective serotonin reuptake inhibitors (SSRIs).
Azapirones have shown benefit in general anxiety and augmenting SSRIs in social anxiety and depression. Evidence is not clear for panic disorder and functional gastrointestinal diseases.
Side effects of azapirones may include dizziness, headaches, restlessness, nausea, and diarrhea.
Azapirones have more tolerable adverse effects than many other available anxiolytics, such as benzodiazepines or SSRIs. Unlike benzodiazepines, azapirones lack abuse potential and are not addictive, do not cause cognitive/memory impairment or sedation, and do not appear to induce appreciable tolerance or physical dependence. However, azapirones are considered less effective with slow onset in controlling symptoms.
The azapirones include the following agents:
So much trouble in the world
So much trouble in the world
Bless my eyes this morning
Jah sun is on the rise once again
The way earthly thin's are goin'
Anything can happen.
You see men sailing on their ego trips,
Blast off on their space ships,
Million miles from reality:
No care for you, no care for me.
So much trouble in the world;
So much trouble in the world.
All you gotta do: Give a little (give a little),
take a little (take a little), give a little (give a little)!
One more time, ye-ah! (give a little) Ye-ah! (take a little)
Ye-ah! (give a little) Yeah!
So you think you've found the solution,
But it's just another illusion!
(So before you check out this tide),
Don't leave another cornerstone
Standing there behind, eh-eh-eh-eh!
We've got to face the day;
(Ooh) Ooh-wee, come what may:
We the street people talkin',
Yeah, we the people strugglin'.
Now they sitting on a time bomb; (Bomb-bomb-bomb! Bomb-bomb-bomb!)
Now I know the time has come: (Bomb-bomb-bomb! Bomb-bomb-bomb!)
What goes on up is coming on down, (Bomb-bomb-bomb! Bomb-bomb-bomb!)
Goes around and comes around. (Bomb-bomb-bomb! Bomb-bomb-bomb!)
So much trouble in the world;
So much trouble in the world;
So much trouble in the world.
There is so much trouble (so much trouble in the world);
There is so much trouble;
There is so much trouble (so much in the world);
There is so much trouble;
There is so much trouble in the world (so much trouble in the world);
There is (so much in the world);