Fab

Fab or FAB may refer to:

Commerce

Culture

Organizations

Science and technology

Fragment antigen-binding

The fragment antigen-binding (Fab) fragment is a region on an antibody that binds to antigens. It is composed of one constant and one variable domain of each of the heavy and the light chain. The variable domain contains the paratope (the antigen-binding site), comprising a set of complementarity determining regions, at the amino terminal end of the monomer. Each arm of the Y thus binds an epitope on the antigen.

In an experimental setting, Fc and Fab fragments can be generated in the laboratory. The enzyme papain can be used to cleave an immunoglobulin monomer into two Fab fragments and an Fc fragment. The enzyme pepsin cleaves below hinge region, so a F(ab')₂ fragment and a pFc' fragment is formed. Recently another enzyme for generation of F(ab')₂ has been commercially available. The enzyme IdeS (Immunoglobulin degrading enzyme from Streptococcus pyogenes, trade name FabRICATOR) cleaves IgG in a sequence specific manner at neutral pH. The F(ab')₂ fragment can be split into two Fab' fragments by mild reduction.

Fab (website)

Fab is an e-commerce company founded in 2010. Once estimated at a worth of over 1 billion dollars, in November 2014, the company was rumored to be in talks to sell for 15 million. In March 2015, PCH International acquired Fab for an undisclosed sum.

It grew from 175,000 members in June 2011, to over 10 million as of December 2012. As of April 30, 2013, Fab has disclosed that it receives 6 million unique visitors per month and have sold over 7 million products since launch. Fab is headquartered in Manhattan and operates a warehouse in Keasbey, New Jersey. The company has office locations in NYC, Pune (India), and Berlin.

History

Fab was founded in February 2010 by Jason Goldberg (entrepreneur) (formerly of XING AG and Jobster) and chief designer Bradford Shellhammer. The site was originally created as a social network for gay men and their friends before pivoting on June 9, 2011 into its model of daily design inspirations and sales. In November 2011, five months after re-launching, Fab reached 1 million members. The company reached this number faster than Facebook, Twitter and Groupon. In September 2012, Fab removed the membership requirements to browse the site. In December 2012, Fab passed 10 million members, up from 7.5 million members in September. Fab also announced it had sold more than 4.3 million products since its launch, averaging 5.4 products sold per minute. In July 2013, fab eliminated 100 positions at its Berlin office as a profit-building measure. Fab laid off 101 more staff, primarily at its New York office in October 2013, further reducing their workforce by 19 percent.

Away

Away may refer to:

Literature

Sports

Music

Songs

See also

Rubberneck (album)

Rubberneck is the most successful album by American rock band The Toadies. It was released in August 1994 on Interscope Records and attained RIAA gold and platinum status in December 1995 and December 1996 respectively. The album produced the band's most popular single, "Possum Kingdom". The song's master track is featured in the Xbox 360 version of the video game Guitar Hero II. It was also released for the video game Rock Band 3 in a pack that contained "Away" and "Tyler" as well.

In 2014, in honor of the album's 20th anniversary, Kirtland Records re-released the album on CD and vinyl on April 1. The album was remastered and also includes five bonus tracks Three of the bonus tracks are previously unreleased songs from the original album's sessions, including "Run in with Dad" and a cover of Pylon's "Stop It", both of which were previously recorded for Velvet, and "Rockfish", an early version of "Waterfall", a song later recorded for Feeler, the intended follow-up to Rubberneck. The other two bonus tracks are early live versions of "Possum Kingdom" and "Tyler", recorded at Trees Dallas on December 5, 1991 The vinyl only features the original 11 album tracks, and includes a download of the five bonus tracks.

Away (Enrique Iglesias song)

"Away" is the first single released from Spanish singer-songwriter Enrique Iglesias' Greatest Hits album. The song features vocals from American pop-rap singer Sean Garrett. The single was released on 11 November 2008. "Away" was originally intended to be on Sean Garrett's debut solo album "Turbo 919", but the decision was made to include it on Iglesias' album instead. The song debuted on the UK Singles Chart, at #132 on the week of the physical single release.

Music video

The video was directed by Anthony Mandler. The video premiered on TRL on 12 November 2008. The video features a cameo by Sean Garrett. In the video, Iglesias is seen walking through the desert, looking back at the horrible crash in which he has died while his girlfriend, played by Niki Huey, cries hysterically. Most of the video was shot in the desert.

Track listing