Cassius was born in the town of Cyrrhus in Syria, although he once called Alexandria his 'paternal city'. Though his parents were Roman citizens, Avidius Cassius was a descendant of the Roman client-king Antiochus IV Epiphanes of Commagene, who had been dethroned half a century before. Thus, he counted inheritance from the Seleucid dynasty, which once ruled many eastern Roman provinces.