Avenue (Charlotte)
Avenue is a 425 feet (130 m) tall skyscraper in Charlotte, North Carolina. It was completed in 2007 and has 36 floors. Its construction began on May 17, 2005. It has 6,700 square feet (620 m2) of retail space at street level. The average unit size of its 386 apartments is 900 sq ft (80 m2). The 0.8 acres (3,237.5 m2) site was originally proposed 201 North Tryon Residential Tower.
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Avenue (band)
Avenue are an English boy band. They participated in the third series of The X Factor in 2006 and initially made it to the final 12, but were banned from participation for having been specifically formed for the competition and having professional representation. They continued to proclaim their innocence.
After leaving The X Factor, they stayed together and had brief success with the single "Last Goodbye", which reached the UK top 50. After the split, Max George went on to become a member of the British-Irish boyband The Wanted, releasing a number of top 5 hits, two official UK number ones, and three top 10 albums. Jamie Tinkler left to form the indie band Baxter, and his replacement in Avenue, Andy Brown, went on to be the lead singer of Lawson, who have released five top 5 singles.
History
2005–06: Beginnings
Max George was born in 1988 grew up with his family in Manchester Before music, he had been a football player with Preston North End and on the verge of signing a two-year deal with them. But because of an accident he had dropped his sport dreams to join Avenue and apply for auditions in The X Factor. After the break-up of the band, he joined the successful chart topping boy band The Wanted. George was engaged to actress Michelle Keegan, but called off the engagement. Despite the calling off of their engagement, the couple remained together for some time. However, they have now split up due to rumours spreading about Max cheating.
6½ Avenue
6½ Avenue is a north-south pedestrian passageway in Midtown Manhattan, New York City, running from West 57th to West 51st Streets between Sixth and Seventh Avenues.
The pedestrian-only avenue is a quarter-mile corridor of privately owned public spaces, such as open-access lobbies and canopied space, which are open except at night. There are stop signs and stop ahead signs at six crossings between 51st and 56th Streets. The mid-block crossing at 57th Street is equipped with a traffic light. At the crosswalk areas, there are sidewalk pedestrian ramps with textured surface and flexible delineators to prevent vehicles parking in the areas.
Each intersection along the thoroughfare has a street name sign that reads "6½ AV" and the name of the cross street to officially mark the street name. The mid-block stop signs are unusual for Manhattan, and the fractional avenue name is a new idea for the numbered street system of New York City.
History
In 2011, the Friends of Privately Owned Public Spaces proposed the creation of a six-block pathway from 51st to 57th Streets that would be mid-block between Sixth and Seventh Avenues to ease pedestrian traffic. The proposal called for connecting public spaces in the area, that were not known to most pedestrians, into a pedestrian corridor and naming it Holly Whyte Way. The idea was presented to the Community Board 5 Transportation Committee and the full Community Board 5, then the board sent a formal request to the New York City Department of Transportation (NYCDOT) in May 2011.
MKL1
MKL/megakaryoblastic leukemia 1 is a protein that in humans is encoded by the MKL1 gene.
Function
The protein encoded by this gene interacts with the transcription factor serum response factor, a key regulator of smooth muscle cell differentiation. It is closely related to MKL2 and myocardin. The encoded protein can shuttle between the cytoplasm and the nucleus, and may help this way transduce signals from the cytoskeleton to the nucleus.
Clinical significance
This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.
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Further reading
MKL
MKL may refer to:
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