Autacoids or "autocoids" are biological factors which act like local hormones, have a brief duration, and act near the site of synthesis. The word autacoids comes from the Greek "Autos" (self) and "Acos" (relief, i.e. drug). The effect of autacoids are mostly localized but large amounts can be produced and moved into circulation. Autacoids may thus have systemic effect by being transported via circulation. These regulating molecules are also metabolized locally. So the compounds are produced locally, they act locally and are metabolised locally. Autacoids can have many different biological actions including modulation of the activity of smooth muscles, glands, nerves, platelets and other tissues.
Some other autacoids are primarily characterized by the effect they have upon different tissues, such as smooth muscle. With respect to vascular smooth muscle, there are both vasoconstrictor and vasodilator autacoids.
Vasodilator autacoids can be released during periods of exercise. Their main effect is seen in the skin, allowing for heat loss.
Last night on the 2, ride home. I swear man I saw an angel.
But when I looked again man, it was just another stranger.
Last night I saw liquor land, man I had a big mission.
13 horsemen riding on and off wind, so I turn my color to the gold.
Got back in my ride, turn up that stereo.
Man what do you have, that you don't need.
We need it all down here!
Temptation, redemption, the Bottle and the Cross.
Life's illusion, from everything you've done.
And somewhere out there,
I hear a SCREAM!
Last night in brigham circle the devil tried to mug me.
And I said: "Man what do I got, you don't got allready?"
You know he looked up to me and said: "Maybe you're right"
Maybe I got something else for you tonight,
He said: "Man what do you need, that you don't own?"
"We got it all down here!"
Temptation, redemption, the Bottle and the Cross.
Life's illusion, from everything you've done.
And somewhere out there over the airwaves,
I hear a SCREAM!
And when the music takes control, it's allright by me.
Ooh another moon rise competing with the lights of the bright city.
Caught between the drum and the baseline, you know it's allright.
SAM System homing like a 737's come to take me back home.