Aurora A kinase

Aurora kinase A also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the AURKA gene.

Aurora A is a member of a family of mitotic serine/threonine kinases. It is implicated with important processes during mitosis and meiosis whose proper function is integral for healthy cell proliferation. Aurora A is activated by one or more phosphorylations and its activity peaks during the G2 phase to M phase transition in the cell cycle.

Discovery

The aurora kinases were first identified in 1990 during a cDNA screen of Xenopus eggs. The kinase discovered, Eg2, is now referred to as Aurora A. It was not until 1998, however, that Aurora A's meiotic and mitotic importance was realized.

Aurora kinase family

The human genome contains three members the Aurora kinase family: Aurora A kinase, Aurora B kinase and Aurora C kinase. The Xenopus, Drosophila, and Caenorhabditis elegans genomes, on the other hand, contain orthologues only to Aurora A and Aurora B.

Ordered pair

In mathematics, an ordered pair (a, b) is a pair of mathematical objects. The order in which the objects appear in the pair is significant: the ordered pair (a, b) is different from the ordered pair (b, a) unless a = b. (In contrast, the unordered pair {a, b} equals the unordered pair {b, a}.)

Ordered pairs are also called 2-tuples, or sequences of length 2; ordered pairs of scalars are also called 2-dimensional vectors. The entries of an ordered pair can be other ordered pairs, enabling the recursive definition of ordered n-tuples (ordered lists of n objects). For example, the ordered triple (a,b,c) can be defined as (a, (b,c)), i.e., as one pair nested in another.

In the ordered pair (a, b), the object a is called the first entry, and the object b the second entry of the pair. Alternatively, the objects are called the first and second coordinates, or the left and right projections of the ordered pair.

Cartesian products and binary relations (and hence functions) are defined in terms of ordered pairs.

A&B

A&B may refer to:

AB

AB, Ab, or ab may refer to:

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