Atod

Atod AB/LG Software AB (also known as 42-Bit AB) was a video game developer located in Helsingborg, Sweden. It was established in 1987 and formally incorporated as company in 1992 by the game development duo Christofer Nilsson and Thomas Liljetoft and active until 2003 when it was merged with British game developer Warthog Games and renamed to Warthog Sweden. In May 2006, the company was acquired by British publisher and developer Eidos Interactive. Today the company is part of the SCi Entertainment Group who acquired Eidos Interactive in 2006.

Games

SOCS3

Suppressor of cytokine signaling 3 (SOCS3 or SOCS-3) is a protein that in humans is encoded by the SOCS3 gene. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling.

Function

The expression of SOCS3 gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma.

For signaling of IL-6, Epo, GCSF and Leptin, binding of SOCS3 to the respective cytokine receptor has been found to be crucial for the inhibitory function of SOCS3.

SOCS3 contributes to both leptin resistance and insulin resistance as a result of increased ceramide synthesis.

Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.

The SOCS3 protein can bind to JAK2 kinase, and inhibits the activity of JAK2 kinase.

Interactions

SOCS3 has been shown to interact with: