Atherosclerosis

Atherosclerosis (also known as arteriosclerotic vascular disease or ASVD) is a specific form of arteriosclerosis in which an artery wall thickens as a result of invasion and accumulation of white blood cells (WBCs) (foam cell) and proliferation of intimal smooth muscle cell creating a fibrofatty plaque.

The accumulation of the WBCs is termed "fatty streaks" early on because of the appearance being similar to that of marbled steak. These accumulations contain both living, active WBCs (producing inflammation) and remnants of dead cells, including cholesterol and triglycerides. The remnants eventually include calcium and other crystallized materials within the outermost and oldest plaque. The "fatty streaks" reduce the elasticity of the artery walls. However, they do not affect blood flow for decades because the artery muscular wall enlarges at the locations of plaque. The wall stiffening may eventually increase pulse pressure; widened pulse pressure is one possible result of advanced disease within the major arteries.

Atherosclerosis (journal)

Atherosclerosis is a monthly peer-reviewed scientific journal established in 1970 and published by Elsevier. It is the official journal of the European Atherosclerosis Society and is affiliated with both the International Atherosclerosis Society and the Society of Atherosclerosis Imaging and Prevention. The editor-in-chief is S. Humphries. According to the Journal Citation Reports, the journal has a 2012 impact factor of 3.706.

Scope

The journal covers all aspects of atherosclerosis and related diseases.

Abstracting and indexing

This journal is abstracted and indexed in:

References

External links