Acetylserotonin O-methyltransferase
N-Acetylserotonin O-methyltransferase also known as ASMT is an enzyme that catalyzes the final reaction in melatonin biosynthesis, converting Normelatonin to melatonin. This reaction is embedded in the more general tryptophan metabolism pathway. The enzyme also catalyzes a second reaction in tryptophan metabolism: the conversion of 5-hydroxy-indoleacetate to 5-methoxy-indoleacetate.
In humans the ASMT enzyme is encoded by the ASMT gene. There are two identical copies, one of which resides on the X chromosome and the other on the Y chromosome.
Structure and Gene Location
N-Acetylserotonin O-methyltransferase is an enzyme that is coded for by genes located on the pseudoautosomal region of the X and Y chromosome, and is most abundantly found in the pineal gland and retina of humans. Although the exact structure of N- Acetylserotonin O-methyltransferase has yet to be determined by X-Ray diffraction, the crystal structure of the Maf domain of human N-Acetylserotonin O-methyltransferase-like protein has been found.
Podcasts:
Easy Meat
by: Frank ZappaFrank Zappa (lead guitar, vocals)
Ike Willis (rhythm guitar, vocals)
Ray White (rhythm guitar, vocals)
Steve Vai (rhythm guitar, vocals)
Warren Cucurullo (rhythm guitar, vocals)
Denny Walley (slide guitar, vocals)
Tommy Mars (keyboards, vocals)
Peter Wolf (keyboards)
Bob Harris (keyboards, trumpet, vocals)
Ed Mann (percussion)
Arthur Barrow (bass, vocals)
Vinnie Colaiuta (drums)
This girl is easy meat
I seen her on the street
See-through blouse an' a tiny little dress
Her manner indiscreet...I knew she was
Easy, easy, easy meat
Easy, easy, easy meat
Easy, easy, easy, easy
Easy meat, easy meat, easy meat, easy meat
She wanna take me home
Make me sweat and moan
Rub my head and beat me off
With a copy of Rollin' Stone
Easy, easy, easy meat
Easy, easy, easy meat
Easy, easy, easy, easy
Easy meat, easy meat, easy meat, easy meat
...They're just not gonna stand for it...
I told her I was late
I had another date
I can't get off on the Rollin' Stone
But the robots think it's great...I knew she was
Easy, easy, easy meat
Easy, easy, easy meat
Easy, easy, Easy, easy
Easy meat, easy meat, easy meat, easy meat
Easy
She was so easy
Easy
Saw her tiny titties
Through her see-through blouse
I just had to take the girl to my house
Easy