1946 was Argentino's most successful year, having reached the 2nd position in the Primera B tournament. Argentino lost its penultimate match against Tiro Federal, and could not reach the promotion to Argentine Primera División.
At the end of the 2005–06 season Argentino narrowly missed out on promotion to Primera B Metropolitana, having reached the playoff final but losing 6–0 on additional time at the hands of Excursionistas.
Argentino has never played at the top level of Argentine football.