Low-density lipoprotein receptor-related protein 8
Low-density lipoprotein receptor-related protein 8 (LRP8), also known as apolipoprotein E receptor 2 (ApoER2), is a protein that in humans is encoded by the LRP8 gene. ApoER2 is a cell surface receptor that is part of the low-density lipoprotein receptor family. These receptors function in signal transduction and endocytosis of specific ligands. Through interactions with one of its ligands, reelin, ApoER2 plays an important role in embryonic neuronal migration and postnatal long-term potentiation. Another LDL family receptor, VLDLR, also interacts with reelin, and together these two receptors influence brain development and function. Decreased expression of ApoER2 is associated with certain neurological diseases.
Structure
ApoER2 is a protein made up of 870 amino acids. It is separated into a ligand binding domain of eight ligand binding regions, an EGF-like domain containing three cysteine-rich repeats, an O-linked glycosylation domain of 89 amino acids, a transmembrane domain of 24 amino acids, and a cytoplasmic domain of 115 amino acids, including an NPXY motif.
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Wojtek - The Soldier Bear
by: ObreroComing from the wilderness
Found by a little boy
Sold to some soldiers
He became their toy
But soon they saw his value
And made him one of them
He helped them fight the evil
Over and over again
Woytek – the soldier bear
Woytek – the soldier bear
He bears the shells
He eats syrup and honey
But also cigarettes
And he drinks beer
Coming from the wilderness
Found by a little boy
Sold to some soldiers
He became their toy
But soon they saw his value
And made him one of them
He helped them fight the evil
Over and over again
Woytek – the soldier bear
Woytek – the soldier bear
He bears the shells
He eats syrup and honey
But also cigarettes
And he drinks beer
From the companies mascot
To their official emblem
The hero of the 22nd
Not like any man
Proud and tall he stands
The grenades in his paws
Marching of to war
Strong forevermore
From the companies mascot
To their official emblem
The hero of the 22nd
Not like any man
Proud and tall he stands
The grenades in his paws
Marching of to war
Strong forevermore
Woytek – the soldier bear