APH-1

APH-1 (anterior pharynx-defective 1) is a protein gene product originally identified in the Notch signaling pathway in Caenorhabditis elegans as a regulator of the cell-surface localization of nicastrin. APH-1 homologs in other organisms, including humans, have since been identified as components of the gamma secretase complex along with the catalytic subunit presenilin and the regulatory subunits nicastrin and PEN-2. The gamma-secretase complex is a multimeric protease responsible for the intramembrane proteolysis of transmembrane proteins such as the Notch protein and amyloid precursor protein (APP). Gamma-secretase cleavage of APP is one of two proteolytic steps required to generate the peptide known as amyloid beta, whose misfolded form is implicated in the causation of Alzheimer's disease. All of the components of the gamma-secretase complex undergo extensive post-translational modification, especially proteolytic activation; APH-1 and PEN-2 are regarded as regulators of the maturation process of the catalytic component presenilin. APH-1 contains a conserved alpha helix interaction motif glycine-X-X-X-glycine (GXXXG) that is essential to both assembly of the gamma secretase complex and to the maturation of the components.

APH

APH or APh may refer to:

2APH

2APH is a radio station based in Albury-Wodonga. It is part of the Vision Australia Radio network, a reading and information service for those persons unable to read or easily access information in print. The station is operated by volunteers.

When not broadcasting local programs, the station is a relay of 3RPH in Melbourne.

References

USS Pinkney (APH-2)

USS Pinkney (APH-2) was a Tryon-class evacuation transport that was assigned to the U.S. Navy during World War II. Pinkney served in the Pacific Ocean theatre of operations and returned home safely post-war with six battle stars but missing 18 crew members who were killed in action.

In 1947 she was acquired by the U.S. Army who renamed her USAT Pvt. Elden H. Johnson and retained her in Army service until 1950 when she was returned to the Navy and assigned to the Military Sea Transportation Service (MSTS) as USNS Pvt. Elden H Johnson (T-AP-184).

Built in Oakland, California

USS Pinkney (APH-2) was laid down as Alcoa Corsair (MC hull 176), 3 June 1941, by the Moore Dry Dock Co., Oakland, California; launched 4 December 1941; sponsored by Miss Ruth Grove; designated for U.S. Navy use and assigned the name Mercy. After the bombing of Pearl Harbor, she was renamed Pinkney, 13 August 1942; acquired, by the U.S. Navy, 27 November 1942; and commissioned the same day, Comdr. A. L. Hutson in command.