Argonaute

The Argonaute protein family plays a central role in RNA silencing processes, as essential catalytic components of the RNA-induced silencing complex (RISC). RISC complex is responsible for the gene silencing phenomenon known as RNA interference (RNAi). Argonaute proteins bind different classes of small non-coding RNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). Small RNAs guide Argonaute proteins to their specific targets through sequence complementarity (base pairing), which then leads to mRNA cleavage or translation inhibition.

Discovery

The RNA interference (RNAi) was first reported in 1995 by Guo and Kemphues, and similar pathways collectively referred to as RNA silencing were discovered in plants and fungi. The beginning of people’s understanding of the mechanism of RNA silencing began only in 1998 with the experiments of Fire and colleagues demonstrating that double-stranded RNA triggered RNAi. RNA silencing pathways process long RNAs into small RNAs that direct the repression of transcription or translation of nucleic acid targets with sequence corresponding to the small RNAs. These single-stranded RNAs, referred to as guide strands, are incorporated into RNA silencing effectors complexes such as the RNA-induced silencing complex (RISC). These RNA silencing effector complexes contain Argonaute family proteins.

Anthem

An anthem is a musical composition of celebration, usually used as a symbol for a distinct group, particularly the national anthems of countries. Originally, and in music theory and religious contexts, it also refers more particularly to short sacred choral work and still more particularly to a specific form of Anglican church music.

Etymology

Anthem is derived from the Greek ἀντίφωνα (antíphōna) via Old English antefn. Both words originally referred to antiphons, a call-and-response style of singing. The adjectival form is "anthemic".

History

Anthems were originally a form of liturgical music. In the Church of England, the rubric appoints them to follow the third collect at morning and evening prayer. Several anthems are included in the British coronation service. The words are selected from Holy Scripture or in some cases from the Liturgy and the music is generally more elaborate and varied than that of psalm or hymn tunes. Being written for a trained choir rather than the congregation, the Anglican anthem is analogous to the motet of the Roman Catholic and Lutheran Churches but represents an essentially English musical form. Anthems may be described as "verse", "full", or "full with verse", depending on whether they are intended for soloists, the full choir, or both.

Anthem (Chess song)

"Anthem" is a song from the concept album and subsequent musical Chess by Tim Rice, Benny Andersson and Björn Ulvaeus. The song describes the feelings of Soviet Russian challenger, Anatoly Sergievsky, when he defects. The song was originally sung by Tommy Körberg on the original concept album]] and as Anatoly in the original West End cast. It was later covered by various artists including Josh Groban on his album Stages and Kerry Ellis.

Plot

Distracted by the loss of Florence's love, Freddie flounders in the chess tournament, leaving himself just one more loss away from losing his title. Florence leaves Freddie, who sends The Arbiter a letter of resignation, resulting in Anatoly's becoming the new world champion. Anatoly immediately defects from the Soviet Union and seeks asylum at the British embassy. Florence, accompanies Anatoly, reflecting on their newfound romance. Walter tips off the press about this scandal. When the mob of reporters ambush Anatoly to ask why he is deserting his country, he tells them in this song that he will never truly leave his country because his land's only borders lie around his heart.

Anthem (N-Joi song)

"Anthem," is a song by the British electronic music group N-Joi. The piano-heavy driven single, which also serves as their debut track, has gone on to become one of their most famous signature songs in the act's career, as well as seeing it chart numerous times since its 1990 release.

Background

The track, which was originally released in 1990, has charted on both the UK and US charts. In its first release, it peaked at number 8 on the UK Pop Chart, but in the United States it had better success on Billboard's Hot Dance Club Play Chart, where it made two trips to the top 5, reaching number 4 in 1991 with the original mixes, and again in 1996, where it was rereleased with new remixes as "The New Anthem" (under the expanded credited "N-Joi featuring Mark Franklin and Nigel Champion"). The updated version would be their second number one in the US, following "Mindflux."

Although the single and the video also features Nigerian singer/actress Saffron, who did the live performances for the act (and whose career would take off after this track), "Anthem" actually features samples of three songs: "Peanut Butter" by Gwen Guthrie (using the lyrics "I'm In Love With You, Want You to Love Me, Too"; Saffron performs the same lyrics in the act's live shows), "I Found Love" by Darlene Davis (using the lyrics "True Love Can Be Hard To Find") and "Back to Life (However Do You Want Me)" by Soul II Soul. Because of this, the artists (and their writers) also receive credits on the single.