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| Identifiers | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Symbol | CLCA_N | ||||||||
| Pfam | PF08434 | ||||||||
| InterPro | IPR013642 | ||||||||
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The family of calcium-activated chloride channels (CLCA) has been identified in many epithelial and endothelial cell types as well as in smooth muscle cells[1] and has four or five putative transmembrane regions. Additionally to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumour suppressors.[2]
Human calcium-activated chloride channels [link]
References [link]
- ^ Ji G, Elble RC, Nehrke K, Debiasio J, Kingsley PD, Kotlikoff MI, Pauli BU (2002). "Molecular and functional characterization of a murine calcium-activated chloride channel expressed in smooth muscle". J. Biol. Chem. 277 (21): 18586–18591. DOI:10.1074/jbc.M200829200. PMID 11896056.
- ^ Evans SR, Thoreson WB, Beck CL (2004). "Molecular and functional analyses of two new calcium-activated chloride channel family members from mouse eye and intestine". J. Biol. Chem. 279 (40): 41792–41800. DOI:10.1074/jbc.M408354200. PMID 15284223.
This article incorporates text from the public domain Pfam and InterPro IPR013642
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