Contact (Fantastic Plastic Machine album)

Contact is a remix album by Fantastic Plastic Machine, released roughly six months after beautiful.. Tanaka enlisted the assistance of several musicians for the project, including Rip Slyme, Kahimi Karie and King Britt. Tanaka also remixed several tracks on the album himself as well as contributing one new song, "City Lights".

The scheduled release date of September 12, 2001, was postponed because of the September 11, 2001 attacks. It was released on October 16, 2001.

Track listing

Contact (1992 film)

Contact is a 1992 short film directed by Jonathan Darby. It was nominated for an Academy Award for Best Live Action Short Film in 1993.

Cast

References

External links

Contact (Freda Payne album)

Contact was Freda Payne's fourth American released album and her second for Invictus Records. The majority of the material on this album contains sad themes, with the exception of "You Brought the Joy." The album begins with a dramatic 11-minute medley of "I'm Not Getting Any Better" and "Suddenly It's Yesterday," both of which were written by Brian Holland and Lamont Dozier. Some people thought that Holland and Dozier were trying to compete with Diana Ross's hit "Ain't No Mountain High Enough" as both songs contain spoken segments and dramatic musical arrangements. The only cover song is "He's in My Life", which was an album track by The Glass House featuring Freda's sister Scherrie Payne. It was written by Brian Holland, Lamont Dozier and Eddie Holland (under their common pseudonym "Edythe Wayne" to avoid copyright claims by their former employer Motown), jointly with Ron Dunbar.

Three singles were lifted from this album: "Cherish What Is Dear to You (While It's Near to You)," "You Brought the Joy," and "The Road We Didn't Take." The anti-war protest song of "Bring the Boys Home" was released before the latter two to high demand and was not included in the first 50,000 copies of this album. After it became a hit (giving Payne her second gold record), it replaced "He's in My Life" as the album's fourth track.

Neurogenic locus notch homolog protein 4

Neurogenic locus notch homolog 4 also known as notch 4 is a protein that in humans is encoded by the NOTCH4 gene located on chromosome 6.

Gene

An alternative splice variant of the NOTCH4 gene has been described, but its biological significance has not been determined.

Structure

The neurogenic locus notch homolog 4 protein is a member of the Notch family. Members of this type 1 transmembrane protein family share structural characteristics. These include an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain that consists of multiple, but different, domain types.

Function

Notch protein family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling pathway is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells

In Drosophilia, notch interacts with its cell-bound ligands (delta and serrate), and establishes an intercellular signaling pathway that then plays a key role in development. Homologues of the notch-ligands have also been identified in humans, but precise interactions between these ligands and the human notch homologues remain to be determined. The notch protein is cleaved in the trans-Golgi network, and then presented on the cell surface as a heterodimer. The protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal, and hepatic development.

Notch 3

Neurogenic locus notch homolog protein 3 is a protein that in humans is encoded by the NOTCH3 gene.

Function

This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined.

Pathology

Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Mutations in NOTCH3 have also been identified in a Turkish family with Alzheimer's disease. Adult Notch3 knock-out mice show incomplete neuronal maturation in the spinal cord dorsal horn, resulting in permanently increased nociceptive sensitivity. Mutations in NOTCH3 are associated to lateral meningocele syndrome .